CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity.

CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Research Abstract Details 

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CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Abstract Text:

Kelly Kent,Kenneth Hess,Susumu Tonegawa,Scott A Small,Kelly Kent,Kenneth Hess,Susumu Tonegawa,Scott A Small,

The anatomical distribution of sensory-evoked activity recorded from the hippocampal long-axis can shift depending on prior experience. In accordance with Marr's computational model of hippocampal function, CA3 NMDA receptors have been hypothesized to mediate this experience-dependent shift in hippocampal activity. Here we tested this hypothesis by investigating genetically-modified mice in which CA3 NMDA receptors are selectively knocked-out (CA3-NR1 KO). First, we were required to develop an fMRI protocol that can record sensory-evoked activity from the mouse hippocampal long-axis. This goal was achieved in part by using a dedicated mouse scanner to image odor-evoked activity, and by using non-EPI (echo planer imaging) pulse sequences. As in humans, odors were found to evoke a ventral-predominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner. Finally, we found that the experience-dependent shift in hippocampal long-axis activity is blocked in CA3-NR1 knock-out mice. These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function.

CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Publishing Authors By Initials

K Kent,K Hess,S Tonegawa,SA Small,K Kent,K Hess,S Tonegawa,SA Small,

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CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hippocampus

VOLUME: 17

Page Numbers: 1003-11

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ISSN: 1050-9631

DAY: 25

MONTH: 09

YEAR: 2007

CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity. Information

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LANGUAGE: eng

NlmUniqueID: 9108167

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Grant and Affiliation Information for CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity.

AFFILIATION: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH058880

ACRONYM: MH

MEDLINETA: Hippocampus

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