C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure.

C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. Research Abstract Details 

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C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. Abstract Text:

S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,M A Morales,S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,M A Morales,S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,M A Morales,

C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well as less load independent parameters as dP/dt. LV ejection fraction (EF), left ventricular end-diastolic dimension (LVEDD) and LV dP/dt were evaluated together with plasma CNP levels in 38 patients with CHF and in 63 controls. CNP levels resulted significantly higher in CHF patients than in controls (7.19+/-0.59pg/ml vs. 2.52+/-0.12pg/ml, p<0.0001). A significant correlation between dP/dt and CNP levels (r=-0.61, p<0.0001) was observed. A good correlation with EF (r=-0.55, p<0.001) and a less significant relation with LVEDD (r=0.316, p<0.05) were also reported. When patients were divided according to dP/dt values a very significant difference in CNP levels was observed: Group I (<600, n=25) vs. Group II (>600, n=13): 8.46+/-0.69 and 4.75+/-0.75pg/ml, respectively, p<0.001. This is the first study that reports a correlation between CNP and dP/dt in CHF patients, thus suggesting a possible role on cardiac contractility.

C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. Publishing Authors By Initials

S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,MA Morales,S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,MA Morales,S Del Ry,M Maltinti,M Cabiati,M Emdin,D Giannessi,MA Morales,

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C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Peptides

VOLUME: 29

Page Numbers: 79-82

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 4

MONTH: 11

YEAR: 2007

C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. Information

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LANGUAGE: eng

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Grant and Affiliation Information for C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure.

AFFILIATION: CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.

Country: United States

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MEDLINETA: Peptides

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