C-peptide in juvenile diabetes.

C-peptide in juvenile diabetes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

C-peptide in juvenile diabetes. Abstract Text:

J Ludvigsson,L G Heding,

C-peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetics with insulin antibodies. At the onset of juvenile diabetes insulin production is thought to be absent or minimal, but we have found rather high levels of C-peptide, even in ketoacidotic patients. The ketoacidosis does not mean an irreversible beta cell failure. In the postinitial remission period with stable metabolism many patients have normal or almost normal C-peptide levels and their beta cells have the capacity to respond to natural stimulation with an increased insulin secretion. For some unknown reason the metabolism becomes more labile coinciding with decreasing C-peptide values. However, even several years beyond the postinitial remission period many juvenile diabetics have some persistent beta cell function, and it has been shown that even trace remnants of beta cell function are of importance for stabilization of the metabolism. There is no reason to believe that the beta cell failure should be predetermined e.g. by genetic factors. However, little is known how to influence the progression and stop the increasing beta cell failure. Some of our results suggest that an early detection and an intensive treatment of diabetes before severe metabolic disturbances and pronounced insulin deficiency have appeared, may increase the possibility of preserving some beta cell function.

C-peptide in juvenile diabetes. Publishing Authors By Initials

J Ludvigsson,LG Heding,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research

PUBMED ID PMID:

MEDLINE DATE:

C-peptide in juvenile diabetes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta paediatrica Scandinavica. Supplement

VOLUME:

Page Numbers: 53-62

Journal Abbreviation:

ISSN: 0300-8843

DAY: 20

MONTH: 02

YEAR: 1977

C-peptide in juvenile diabetes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 173166

C-peptide in juvenile diabetes. Keywords Mesh Terms:

KEYWORDS: Remission, Spontaneous

MESH TERMS: metabolism

Chemical & Substance for Abstract: C-peptide in juvenile diabetes. Information

Substance Name: Proinsulin

Registry Number: 9035-68-1

Grant and Affiliation Information for C-peptide in juvenile diabetes.

AFFILIATION:

Country: SWEDEN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Paediatr Scand Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

C-peptide in juvenile diabetes Related Publications

• C-peptide in juvenile diabetes.
• Effects of exercise on insulin receptors on erythrocytes and monocytes from insulin dependent diabetics.
• Glomerular structural changes in rabbits on treatment with bovine and porcine insulin. A morphometric analysis.
• Increased release of gut glucagon in reactive hypoglycaemia.
• Plasma insulin, C-peptide, and glucagon levels in acute phase of ethanol-induced hypoglycaemia.
• [Diagnosis of insulinomas. Determination of insulin, C-peptide and proinsulin in blood to differentiate between endogenous and exogenous hyperinsulinism]