c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Abstract Text:

Guochun Jiang,Amy Espeseth,Daria J Hazuda,David M Margolis,Guochun Jiang,Amy Espeseth,Daria J Hazuda,David M Margolis,

Histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) induce the expression of quiescent proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral infection in vivo. To uncover novel molecular mechanisms that maintain HIV latency, we sought cellular mRNAs whose expression was diminished in resting CD4(+) T cells of HIV-1-infected patients exposed to VPA. c-Myc was prominent among genes markedly downregulated upon exposure to VPA. c-Myc expression repressed HIV-1 expression in chronically infected cell lines. Chromatin immunoprecipitation (ChIP) assays revealed that c-Myc and HDAC1 are coordinately resident at the HIV-1 long terminal repeat (LTR) promoter and absent from the promoter after VPA treatment in concert with histone acetylation, RNA polymerase II recruitment, and LTR expression. Sequential ChIP assays demonstrated that c-Myc, Sp1, and HDAC1 coexist in the same DNA-protein complex at the HIV promoter. Short hairpin RNA inhibition of c-Myc reduces both c-Myc and HDAC1 occupancy, blocks c-Myc repression of Tat activation, and increases LTR expression. These results expand the understanding of mechanisms that recruit HDAC and maintain the latency of HIV-1, suggesting novel therapeutic approaches against latent proviral HIV infection.

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Publishing Authors By Initials

G Jiang,A Espeseth,DJ Hazuda,DM Margolis,G Jiang,A Espeseth,DJ Hazuda,DM Margolis,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 10914-23

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 1

MONTH: 08

YEAR: 2007

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.

AFFILIATION: Department of Medicine, University of North Carolina at Chapel Hill, 3302 Michael Hooker Research Ctr., Chapel Hill, NC 27599-7435, USA.

Country: United States

AGENCY: United States NIAID

GRANT: P30 AI50410

ACRONYM: AI

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter Related Publications

• "Steel wool keratopathy": a clinical sign of chronic inflammation.
• A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.
• A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array.
• Apical junctional complexes and cell polarity.
• Bex1 knock out mice show altered skeletal muscle regeneration.
• Body dysmorphic disorder symptoms among patients with acne vulgaris.
• Confronting proviral HIV infection.
• Digital imaging of wounds: are measurements reproducible among observers?
• Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions.
• Emergency medical services education: past, present, and future.
• Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium.
• Hepatitis B vaccination of men who have sex with men attending an urban STD clinic: impact of an ongoing vaccination program, 1998-2003.
• Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci.
• Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: a prospective study by AIDS Clinical Trials Group 5170.
• Mammalian lin-7 stabilizes polarity protein complexes.
• Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
• Nuclear receptors and bone.
• Obituary: arun fotedar.
• Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons.
• PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.
• Radiation therapy for cutaneous squamous cell carcinoma involving the parotid area lymph nodes: dose and volume considerations.
• Repeat expansion and autosomal dominant neurodegenerative disorders: consensus and controversy.
• Restricted-carbohydrate diets in patients with type 2 diabetes: a meta-analysis.
• Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time.
• Sodium/calcium exchanger expression in the mouse and rat olfactory systems.
• Spindle cell lipoma of the mediastinum: a differential consideration for liposarcoma.
• The prevalence of atopic triad in children with physician-confirmed atopic dermatitis.
• Upper respiratory tract infection in household contacts of acne patients.
• c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.
• pH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro.