c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Research Abstract Details 

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c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Abstract Text:

Jordane Malaterre,Theo Mantamadiotis,Sebastian Dworkin,Sally Lightowler,Qing Yang,Mark I Ransome,Ann M Turnley,Nancy R Nichols,Nikla R Emambokus,Jon Frampton,Robert G Ramsay,Jordane Malaterre,Theo Mantamadiotis,Sebastian Dworkin,Sally Lightowler,Qing Yang,Mark I Ransome,Ann M Turnley,Nancy R Nichols,Nikla R Emambokus,Jon Frampton,Robert G Ramsay,Jordane Malaterre,Theo Mantamadiotis,Sebastian Dworkin,Sally Lightowler,Qing Yang,Mark I Ransome,Ann M Turnley,Nancy R Nichols,Nikla R Emambokus,Jon Frampton,Robert G Ramsay,

Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Publishing Authors By Initials

J Malaterre,T Mantamadiotis,S Dworkin,S Lightowler,Q Yang,MI Ransome,AM Turnley,NR Nichols,NR Emambokus,J Frampton,RG Ramsay,J Malaterre,T Mantamadiotis,S Dworkin,S Lightowler,Q Yang,MI Ransome,AM Turnley,NR Nichols,NR Emambokus,J Frampton,RG Ramsay,J Malaterre,T Mantamadiotis,S Dworkin,S Lightowler,Q Yang,MI Ransome,AM Turnley,NR Nichols,NR Emambokus,J Frampton,RG Ramsay,

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c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Stem cells (Dayton, Ohio)

VOLUME: 26

Page Numbers: 173-81

Journal Abbreviation: Stem Cells

ISSN: 1549-4918

DAY: 27

MONTH: 09

YEAR: 2007

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. Information

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LANGUAGE: eng

NlmUniqueID: 9304532

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Grant and Affiliation Information for c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.

AFFILIATION: Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

Country: United States

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Stem Cells

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• c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.