c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons.

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Research Abstract Details 

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c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Abstract Text:

J Newbern,A Taylor,M Robinson,M O Lively,C E Milligan,

The c-Jun N-terminal kinases (JNKs) are activated by various stimuli and are critical for neuronal development as well as for death following a stressful stimulus. Here, we have evaluated JNK activity in both healthy and dying motoneurons from developing chick embryos and found no apparent difference in overall JNK activity between the conditions, suggesting that this pathway maybe critical in both circumstances. Pharmacological inhibition of JNK in healthy motoneurons supplied with trophic support resulted in decreased mitochondrial membrane potential, neurite outgrowth, and phosphorylation of microtubule-associated protein 1B. On the other hand, in motoneurons deprived of trophic support, inhibition of JNK attenuated caspase activation, and nuclear condensation. We also examined the role of JNK's downstream substrate c-Jun in mediating these events. While c-Jun expression and phosphorylation were greater in cells supplied with trophic support as compared with those deprived, inhibition of c-Jun had no effect on nuclear condensation in dying cells or neurite outgrowth in healthy cells, suggesting that JNK's role in these events is independent of c-Jun. Together, our data underscore the dualistic nature of JNK signaling that is critical for both survival and degenerative changes in motoneurons.

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Publishing Authors By Initials

J Newbern,A Taylor,M Robinson,MO Lively,CE Milligan,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience

VOLUME: 147

Page Numbers: 680-92

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 20

MONTH: 06

YEAR: 2007

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Information

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LANGUAGE: eng

NlmUniqueID: 7605074

c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons.

AFFILIATION: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS036081

ACRONYM: NS

MEDLINETA: Neuroscience

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