c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes.

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Research Abstract Details 

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c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Abstract Text:

Jianhua Zhang,Lu Zhang,Hongyuan Jiao,Qi Zhang,Dongsheng Zhang,Danwen Lou,Jonathan L Katz,Ming Xu,

Development of drug addiction involves persistent neurobiological changes. The dopamine D1 receptor is involved in mediating cocaine-induced neuroadaptation, yet the underlying intracellular mechanisms remain unclear. We examined a potential role of the immediate early gene Fos, which is robustly and rapidly induced by cocaine via D1 receptors, in mediating cocaine-induced persistent neurobiological changes by creating and analyzing a mouse in which Fos is primarily disrupted in D1 receptor-expressing neurons in the brain. We show that the expression levels of several transcription factors, neurotransmitter receptors, and intracellular signaling molecules induced by repeated cocaine administration are altered in Fos-deficient brains. Dendritic remodeling of medium spiny neurons induced by repeated exposure to cocaine is blunted in the mutant mice. The mutant mice exhibit attenuated behavioral sensitization after repeated exposure to cocaine and more persistent memory of cocaine-induced conditioned place preference. Our findings indicate that c-Fos produced in D1 receptor-expressing neurons integrates mechanisms to facilitate both the acquisition and extinction of cocaine-induced persistent changes.

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Publishing Authors By Initials

J Zhang,L Zhang,H Jiao,Q Zhang,D Zhang,D Lou,JL Katz,M Xu,

For similar proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d1 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, dopamine: receptors, dopamine d1 research

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c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 26

Page Numbers: 13287-96

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 20

MONTH: Dec

YEAR: 2006

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Keywords Mesh Terms:

KEYWORDS: Receptors, Dopamine D1

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. Information

Substance Name: Cocaine

Registry Number: 50-36-2

Grant and Affiliation Information for c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes.

AFFILIATION: Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Country: United States

AGENCY: United States NIDA

GRANT: DA17323

ACRONYM: DA

MEDLINETA: J Neurosci

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