C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease.

C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Research Abstract Details 

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C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Abstract Text:

Christopher D Link,

Caenorhabditis elegans has been used to model aspects of a number of age-associated neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases. These models have typically involved the transgenic expression of disease-associated human proteins. Here I describe my laboratory's specific experience engineering C. elegans models of Alzheimer's disease, and give a general consideration of the advantages and disadvantages of these C. elegans models. The type of insights that might be gained from using these (relatively) simple models are highlighted. In particular, I consider the potential these models have for uncovering common and unique fundamental toxic mechanisms underlying human neurodegenerative diseases.

C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Publishing Authors By Initials

CD Link,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

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C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Experimental gerontology

VOLUME: 41

Page Numbers: 1007-13

Journal Abbreviation: Exp. Gerontol.

ISSN: 0531-5565

DAY: 23

MONTH: 08

YEAR: 2006

C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Information

Number of References: 42

LANGUAGE: eng

NlmUniqueID: 47061

C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Information

Substance Name: tau Proteins

Registry Number: 0

Grant and Affiliation Information for C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease.

AFFILIATION: Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA. linkc@colorado.edu

Country: England

AGENCY: United States NIA

GRANT: AG21037

ACRONYM: AG

MEDLINETA: Exp Gerontol

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