Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries.

Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Research Abstract Details 

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Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Abstract Text:

Xiao-ming Liu,Mohammed A Azam,Kelly J Peyton,Diana Ensenat,Amit N Keswani,Hong Wang,William Durante,

OBJECTIVE: Butylated hydroxyanisole (BHA) is a synthetic phenolic compound that is a potent inducer of phase II genes. Since heme oxygenase-1 (HO-1) is a vasoprotective protein that is upregulated by phase II inducers, the present study examined the effects of BHA on HO-1 gene expression and vascular smooth muscle cell proliferation. METHODS: The regulation of HO-1 gene expression and vascular cell growth by BHA was studied in cultured rat aortic smooth muscle cells and in balloon injured rat carotid arteries. RESULTS: Treatment of cultured smooth muscle cells with BHA stimulated the expression of HO-1 protein, mRNA and promoter activity in a time- and concentration-dependent manner. BHA-mediated HO-1 expression was dependent on the activation of NF-E2-related factor-2 by p38 mitogen-activated protein kinase. BHA also inhibited cell cycle progression and DNA synthesis in an HO-1-dependent manner. In addition, the local perivascular delivery of BHA immediately after arterial injury of rat carotid arteries induced HO-1 protein expression and markedly attenuated neointima formation. CONCLUSIONS: These studies demonstrate that BHA stimulates HO-1 gene expression in vascular smooth muscle cells, and that the induction of HO-1 contributes to the antiproliferative actions of this phenolic antioxidant. BHA represents a potentially novel therapeutic agent in treating or preventing vasculoproliferative disease.

Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Publishing Authors By Initials

XM Liu,MA Azam,KJ Peyton,D Ensenat,AN Keswani,H Wang,W Durante,

For similar cardiovascular system: blood vessels: endothelium, vascular: tunica intima research abstracts see: cardiovascular system: blood vessels: endothelium, vascular: tunica intima research

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Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cardiovascular research

VOLUME: 74

Page Numbers: 169-79

Journal Abbreviation: Cardiovasc. Res.

ISSN: 0008-6363

DAY: 27

MONTH: 01

YEAR: 2007

Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 77427

Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Keywords Mesh Terms:

KEYWORDS: Tunica Intima

MESH TERMS: pathology

Chemical & Substance for Abstract: Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries. Information

Substance Name: Heme Oxygenase-1

Registry Number: EC 1.14.99.3

Grant and Affiliation Information for Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries.

AFFILIATION: Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R01 HL059976-08

ACRONYM: HL

MEDLINETA: Cardiovasc Res

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