Building and validating a prognostic index for biomarker studies.

Building and validating a prognostic index for biomarker studies. Research Abstract Details 

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Building and validating a prognostic index for biomarker studies. Abstract Text:

Xuelin Huang,Swati Biswas,Elihu H Estey,Donald A Berry,

An important aspect of modern cancer research is identifying molecular and genetic markers that predict an individual's risk of recurrence and response to treatment. Increasingly, a large number of biomarkers are included in studies, even though at most a small proportion of them will be prognostic. This article considers the selection and validation of prognostic biomarkers, and proposes a method for building and validating a prognostic index based on potentially many markers. We use simulation to show that our proposed method controls false-positive rate while retaining reasonable power. The prognostic index gets its power from combining prognostic biomarkers. It can be very powerful even when there are few markers that are predictive.

Building and validating a prognostic index for biomarker studies. Publishing Authors By Initials

X Huang,S Biswas,EH Estey,DA Berry,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Building and validating a prognostic index for biomarker studies. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Cancer biomarkers : section A of Disease markers

VOLUME: 2

Page Numbers: 97-101

Journal Abbreviation:

ISSN: 1574-0153

DAY: 3

MONTH: 12

YEAR: 2006

Building and validating a prognostic index for biomarker studies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101256509

Building and validating a prognostic index for biomarker studies. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

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Chemical & Substance for Abstract: Building and validating a prognostic index for biomarker studies. Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for Building and validating a prognostic index for biomarker studies.

AFFILIATION: Department of Biostatistics & Applied Mathematics, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: 1 P01 CA108631-01

ACRONYM: CA

MEDLINETA: Cancer Biomark

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