BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts.

BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Research Abstract Details 

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BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Abstract Text:

Yue Wang,Ming Zhang,Yurong Tan,Yang Xiang,Huijun Liu,Fei Qu,Ling Qin,Xiaoqun Qin,Yue Wang,Ming Zhang,Yurong Tan,Yang Xiang,Huijun Liu,Fei Qu,Ling Qin,Xiaoqun Qin,Yue Wang,Ming Zhang,Yurong Tan,Yang Xiang,Huijun Liu,Fei Qu,Ling Qin,Xiaoqun Qin,

Airway re-modelling in asthma usually results in an irreversible weakness of pulmonary ventilation, however, its initiating or controlling mechanism remains unclear. In this study, we hypothesize that signal communication between airway epithelial cells and sub-mucosal fibroblast cells may play an important role in the maintenance of structure homeostasis in a physiologic condition and in initiation of airway remodelling in a stressed condition. To test the hypothesis, a co-cultured system of human bronchial epithelial cells (BEC) and human lung fibroblasts (HLF) were designed to observe the effects of BEC, in the normal state or in a BRS-3 activated state, on the proliferation and collagen synthesis of HLF. The results showed that the proliferation activities of both BEC and HLF inhibited each other under the normal state. BRS-3-activated BEC can transform the reciprocal inhibition into promoting effects. The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF. The proliferation activities of HLF were weakened by co-culture with TGF-beta1 antisense oligonucleotides (ASO) treated BEC. It was concluded that, in the normal state, BEC inhibits the activities of fibroblasts through release of PGE2 to maintain the airway homeostasis; however when stressed, for example by BRS-3 activation, BEC promote the activities of fibroblasts mediated by TGF-beta1, thereby facilitating the airway re-modelling.

BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Publishing Authors By Initials

Y Wang,M Zhang,Y Tan,Y Xiang,H Liu,F Qu,L Qin,X Qin,Y Wang,M Zhang,Y Tan,Y Xiang,H Liu,F Qu,L Qin,X Qin,Y Wang,M Zhang,Y Tan,Y Xiang,H Liu,F Qu,L Qin,X Qin,

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BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell biology international

VOLUME: 31

Page Numbers: 1495-500

Journal Abbreviation: Cell Biol. Int.

ISSN: 1065-6995

DAY: 15

MONTH: 07

YEAR: 2007

BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. Information

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LANGUAGE: eng

NlmUniqueID: 9307129

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Grant and Affiliation Information for BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts.

AFFILIATION: Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China.

Country: England

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MEDLINETA: Cell Biol Int

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