Bronchopulmonary neuroendocrine tumors.

Bronchopulmonary neuroendocrine tumors. Research Abstract Details 

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Bronchopulmonary neuroendocrine tumors. Abstract Text:

Bronchopulmonary neuroendocrine tumors (BP-NETs) comprise approximately 20% of all lung cancers and represent a spectrum of tumors arising from neuroendocrine cells of the BP-epithelium. Although they share structural, morphological, immunohistochemical, and ultrastructural features, they are separated into 4 subgroups: typical carcinoid tumor (TC), atypical carcinoid tumor (AC), large-cell neuroendocrine carcinoma (LCNEC), and small-cell lung carcinoma (SCLC), which exhibit considerably different biological characteristics. The clinical presentation includes cough, hemoptysis, and obstructive pneumonia but varies depending on site, size, and growth pattern. Less than 5% of BP-NETs exhibit hormonally related symptoms such as carcinoid syndrome, Cushing, acromegaly, and SIADH. SCLC is the most common BP-NET, while LCNEC is rare, approximately 10% and

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PUBLICATION TYPE: Journal Article

Journal: Cancer

VOLUME: 113

Page Numbers: 5-21

Journal Abbreviation: Cancer

ISSN: 0008-543X

DAY: 1

MONTH: Jul

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 374236

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Grant and Affiliation Information for Bronchopulmonary neuroendocrine tumors.

AFFILIATION: Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.

Country: United States

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MEDLINETA: Cancer

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