Bronchial responsiveness in atopic adults increases with exposure to cat allergen.

Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Research Abstract Details 

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Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Abstract Text:

Susan Chinn,Joachim Heinrich,Josep M ,Christer Janson,Dan ,Mario Olivieri,Cecilie Svanes,Jordi Sunyer,Giuseppe Verlato,Matthias Wjst,Jan-Paul Zock,Peter G Burney,Deborah L Jarvis,

RATIONALE: The association of asthma with sensitization and allergen exposure is known to be complex. There have been few studies of bronchial responsiveness in relation to both risk factors in adults. OBJECTIVES: To determine the relation of bronchial responsiveness to allergen exposure and IgE sensitization in a community study taking into account the major determinants of bronchial responsiveness in adulthood. METHODS: Cross-sectional data were drawn from 1,884 participants in 20 centers in the European Community Respiratory Health Survey follow-up, which included measurement of house dust mite and cat allergen in mattress dust samples, and IgE sensitization to four allergens. Bronchial responsiveness to methacholine was expressed as a continuous variable, and analyzed by multiple regression. MEASUREMENTS AND MAIN RESULTS: The trend toward greater bronchial responsiveness with increasing exposure to cat allergen was greater in those sensitized to any of the four allergens than those not sensitized (p = 0.001); there was no significant interaction between cat sensitization and Fel d 1 exposure. No trend was found with house dust mite allergen exposure. The difference in bronchial responsiveness between those exposed to the highest levels compared with the lowest was approximately -2.02 doubling doses of PD20 (95% confidence interval, -3.06 to -0.97), and nearly as great in those exposed to more moderate levels. CONCLUSIONS: Cat allergen exposure at moderate levels may be harmful to all atopic adults. The clinical implication is that it is insufficient to test patients with asthma for cat sensitization; all atopic individuals may benefit from reduced cat exposure.

Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Publishing Authors By Initials

S Chinn,J Heinrich,JM ,C Janson,D ,M Olivieri,C Svanes,J Sunyer,G Verlato,M Wjst,JP Zock,PG Burney,DL Jarvis,

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of respiratory and critical care

VOLUME: 176

Page Numbers: 20-6

Journal Abbreviation: Am. J. Respir. Crit. Care Med.

ISSN: 1535-4970

DAY: 19

MONTH: 04

YEAR: 2007

Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Information

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LANGUAGE: eng

NlmUniqueID: 9421642

Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: immunology

Chemical & Substance for Abstract: Bronchial responsiveness in atopic adults increases with exposure to cat allergen. Information

Substance Name: Dermatophagoides farinae antigen f 1

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Bronchial responsiveness in atopic adults increases with exposure to cat allergen.

AFFILIATION: Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London, United Kingdom. s.chinn@imperial.ac.uk

Country: United States

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MEDLINETA: Am J Respir Crit Care Med

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