Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children.

Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Research Abstract Details 

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Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Abstract Text:

Megan R Gunnar,Philip A Fisher, ,

A major focus in developmental psychopathology is on understanding developmental mechanisms and, armed with this information, intervening to improve children's outcomes. Translational research attempts to bridge the distance between understanding and intervention. In the collaborations that have formed the core of our research network on early experience, stress, and prevention science, we have focused on translating basic research on early experiences and stress neurobiology into preventive interventions for neglected and abused children. Our experiences in attempting to move from bench to bedside have led us to recognize the many challenges that face translational researchers. This review provides a brief synopsis of the animal model literature on early experience and stress neurobiology from which we glean several key bridging issues. We then review what is currently known about the impact of childhood neglect and abuse on stress neurobiology in human adults and children. Next, we describe how this work has informed the evaluation of our preventive interventions with maltreated children. Finally, we discuss several considerations that should facilitate a more complete integration of basic research on early experience and stress neurobiology into preventive intervention strategies.

Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Publishing Authors By Initials

MR Gunnar,PA Fisher, ,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: stress, psychological research

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MEDLINE DATE:

Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Journal Published:

PUBLICATION TYPE: Review

Journal: Development and psychopathology

VOLUME: 18

Page Numbers: 651-77

Journal Abbreviation: Dev. Psychopathol.

ISSN: 0954-5794

DAY: 3

MONTH: 12

YEAR: 2006

Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Information

Number of References: 128

LANGUAGE: eng

NlmUniqueID: 8910645

Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Keywords Mesh Terms:

KEYWORDS: Stress, Psychological

MESH TERMS: psychology

Chemical & Substance for Abstract: Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children. Information

Substance Name: Corticotropin-Releasing Hormone

Registry Number: 9015-71-8

Grant and Affiliation Information for Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children.

AFFILIATION: Institute of Child Development, University of Minnesota, Minneapolis, USA. gunnar@umn.edu

Country: United States

AGENCY: United States NIMH

GRANT: R21 MH65046

ACRONYM: MH

MEDLINETA: Dev Psychopathol

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