Bridging the gap in RNA structure prediction.

Bridging the gap in RNA structure prediction. Research Abstract Details 

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Bridging the gap in RNA structure prediction. Abstract Text:

Bruce A Shapiro,Yaroslava G Yingling,Wojciech Kasprzak,Eckart Bindewald,

The field of RNA structure prediction has experienced significant advances in the past several years, thanks to the availability of new experimental data and improved computational methodologies. These methods determine RNA secondary structures and pseudoknots from sequence alignments, thermodynamics-based dynamic programming algorithms, genetic algorithms and combined approaches. Computational RNA three-dimensional modeling uses this information in conjunction with manual manipulation, constraint satisfaction methods, molecular mechanics and molecular dynamics. The ultimate goal of automatically producing RNA three-dimensional models from given secondary and tertiary structure data, however, is still not fully realized. Recent developments in the computational prediction of RNA structure have helped bridge the gap between RNA secondary structure prediction, including pseudoknots, and three-dimensional modeling of RNA.

Bridging the gap in RNA structure prediction. Publishing Authors By Initials

BA Shapiro,YG Yingling,W Kasprzak,E Bindewald,

For similar natural sciences: physics: thermodynamics research abstracts see: natural sciences: physics: thermodynamics research

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Bridging the gap in RNA structure prediction. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in structural biology

VOLUME: 17

Page Numbers: 157-65

Journal Abbreviation:

ISSN: 0959-440X

DAY: 23

MONTH: 03

YEAR: 2007

Bridging the gap in RNA structure prediction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107784

Bridging the gap in RNA structure prediction. Keywords Mesh Terms:

KEYWORDS: Thermodynamics

MESH TERMS: genetics

Chemical & Substance for Abstract: Bridging the gap in RNA structure prediction. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Bridging the gap in RNA structure prediction.

AFFILIATION: Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA. bshapiro@ncifcrf.gov

Country: England

AGENCY: United States NCI

GRANT: N01 CO12400

ACRONYM: CO

MEDLINETA: Curr Opin Struct Biol

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