Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation.

Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Research Abstract Details 

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Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Abstract Text:

Shoubin Tang,Chao Yang,Peggy Brodie,Susan Bane,Rudravajhala Ravindra,Shubhada Sharma,Yi Jiang,James P Snyder,David G I Kingston,

The synthesis of the bridged A-nor-paclitaxel 4 has been achieved from paclitaxel in a key test of the T-Taxol conformational hypothesis. Although the unbridged A-nor-paclitaxel 3 is essentially noncytotoxic, the bridged analogue 4 is strongly cytotoxic. This result provides strong evidence for the T-Taxol conformation as the bioactive tubulin-binding conformation of paclitaxel.

Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Publishing Authors By Initials

S Tang,C Yang,P Brodie,S Bane,R Ravindra,S Sharma,Y Jiang,JP Snyder,DG Kingston,

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Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic letters

VOLUME: 8

Page Numbers: 3983-6

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ISSN: 1523-7060

DAY: 31

MONTH: Aug

YEAR: 2006

Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation. Information

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LANGUAGE: eng

NlmUniqueID: 100890393

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Grant and Affiliation Information for Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation.

AFFILIATION: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

Country: United States

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MEDLINETA: Org Lett

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