Breast milk iodine and perchlorate concentrations in lactating Boston-area women.

Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Research Abstract Details 

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Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Abstract Text:

Elizabeth N Pearce,Angela M Leung,Benjamin C Blount,Hamid R Bazrafshan,Xuemei He,Sam Pino,Liza Valentin-Blasini,Lewis E Braverman,

CONTEXT: Breastfed infants rely on adequate maternal dietary iodine intake. OBJECTIVE: Our objective was to measure breast milk iodine and perchlorate, an inhibitor of iodide transport into the thyroid and potentially into breast milk, in Boston-area women. PARTICIPANTS: The study included 57 lactating healthy volunteers in the Boston area. MEASUREMENTS: Breast milk iodine and perchlorate concentrations and urine iodine, perchlorate, and cotinine concentrations were measured. For comparison, iodine and perchlorate levels in infant formulae were also measured. RESULTS: Median breast milk iodine content in 57 samples was 155 microg/liter (range, 2.7-1968 microg/liter). Median urine iodine was 114 microg/liter (range, 25-920 microg/liter). Perchlorate was detectable in all 49 breast milk samples (range, 1.3-411 microg/liter), all 56 urine samples (range, 0.37-127 microg/liter), and all 17 infant formula samples (range, 0.22-4.1 microg/liter) measured. Breast milk iodine content was significantly correlated with urinary iodine per gram creatinine and urinary cotinine but was not significantly correlated with breast milk or urinary perchlorate. CONCLUSIONS: Perchlorate exposure was not significantly correlated with breast milk iodine concentrations. Perchlorate was detectable in infant formula but at lower levels than in breast milk. Forty-seven percent of women sampled may have been providing breast milk with insufficient iodine to meet infants' requirements.

Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Publishing Authors By Initials

EN Pearce,AM Leung,BC Blount,HR Bazrafshan,X He,S Pino,L Valentin-Blasini,LE Braverman,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

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Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 1673-7

Journal Abbreviation:

ISSN: 0021-972X

DAY: 20

MONTH: 02

YEAR: 2007

Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: metabolism

Chemical & Substance for Abstract: Breast milk iodine and perchlorate concentrations in lactating Boston-area women. Information

Substance Name: Perchloric Acid

Registry Number: 7601-90-3

Grant and Affiliation Information for Breast milk iodine and perchlorate concentrations in lactating Boston-area women.

AFFILIATION: Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center and Boston University School of Medicine, 88 East Newton Street, Evans 201, Boston, MA 02118, USA. elizabeth.pearce@bmc.org

Country: United States

AGENCY: United States NCRR

GRANT: M01 RR 00533

ACRONYM: RR

MEDLINETA: J Clin Endocrinol Metab

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