Breast cancer: origins and evolution.

Breast cancer: origins and evolution. Research Abstract Details 

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Breast cancer: origins and evolution. Abstract Text:

Kornelia Polyak,Kornelia Polyak,

Breast cancer is not a single disease, but rather is composed of distinct subtypes associated with different clinical outcomes. Understanding this heterogeneity is key for the development of targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- and intratumoral diversity are the cancer stem cell and the clonal evolution hypotheses. Although tumor initiation and progression are predominantly driven by acquired genetic alterations, recent data implicate a role for microenvironmental and epigenetic changes as well. Comprehensive unbiased studies of tumors and patient populations have significantly advanced our molecular understanding of breast cancer, but translating these findings into clinical practice remains a challenge.

Breast cancer: origins and evolution. Publishing Authors By Initials

K Polyak,K Polyak,

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Breast cancer: origins and evolution. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 3155-63

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 2

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7802877

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Grant and Affiliation Information for Breast cancer: origins and evolution.

AFFILIATION: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. kornelia_polyak@dfci.harvard.edu

Country: United States

AGENCY: United States NCI

GRANT: CA94074

ACRONYM: CA

MEDLINETA: J Clin Invest

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