Breast cancer metastases are molecularly distinct from their primary tumors.

Breast cancer metastases are molecularly distinct from their primary tumors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Breast cancer metastases are molecularly distinct from their primary tumors. Abstract Text:

M Vecchi,S Confalonieri,P Nuciforo,M A ,M Capra,M Bianchi,D Nicosia,F Bianchi,V Galimberti,G Viale,G Palermo,A Riccardi,R Campanini,M G Daidone,M A Pierotti,S Pece,P P Di Fiore,M Vecchi,S Confalonieri,P Nuciforo,M A ,M Capra,M Bianchi,D Nicosia,F Bianchi,V Galimberti,G Viale,G Palermo,A Riccardi,R Campanini,M G Daidone,M A Pierotti,S Pece,P P Di Fiore,

Metastases have been widely thought to arise from rare, selected, mutation-bearing cells in the primary tumor. Recently, however, it has been proposed that breast tumors are imprinted ab initio with metastatic ability. Thus, there is a debate over whether 'phenotypic' disease progression is really associated with 'molecular' progression. We profiled 26 matched primary breast tumors and lymph node metastases and identified 270 probesets that could discriminate between the two categories. We then used an independent cohort of breast tumors (81 samples) and unmatched distant metastases (32 samples) to validate and refine this list down to a 126-probeset list. A representative subset of these genes was subjected to analysis by in situ hybridization, on a third independent cohort (57 primary breast tumors and matched lymph node metastases). This not only confirmed the expression profile data, but also allowed us to establish the cellular origin of the signals. One-third of the analysed representative genes (4 of 11) were expressed by the epithelial component. The four epithelial genes alone were able to discriminate primary breast tumors from their metastases. Finally, engineered alterations in the expression of two of the epithelial genes (SERPINB5 and LTF) modified cell motility in vitro, in accordance with a possible causal role in metastasis. Our results show that breast cancer metastases are molecularly distinct from their primary tumors.Oncogene (2008) 27, 2148-2158; doi:10.1038/sj.onc.1210858; published online 22 October 2007.

Breast cancer metastases are molecularly distinct from their primary tumors. Publishing Authors By Initials

M Vecchi,S Confalonieri,P Nuciforo,MA ,M Capra,M Bianchi,D Nicosia,F Bianchi,V Galimberti,G Viale,G Palermo,A Riccardi,R Campanini,MG Daidone,MA Pierotti,S Pece,PP Di Fiore,M Vecchi,S Confalonieri,P Nuciforo,MA ,M Capra,M Bianchi,D Nicosia,F Bianchi,V Galimberti,G Viale,G Palermo,A Riccardi,R Campanini,MG Daidone,MA Pierotti,S Pece,PP Di Fiore,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Breast cancer metastases are molecularly distinct from their primary tumors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncogene

VOLUME: 27

Page Numbers: 2148-58

Journal Abbreviation:

ISSN: 1476-5594

DAY: 22

MONTH: 10

YEAR: 2007

Breast cancer metastases are molecularly distinct from their primary tumors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

Breast cancer metastases are molecularly distinct from their primary tumors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Breast cancer metastases are molecularly distinct from their primary tumors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Breast cancer metastases are molecularly distinct from their primary tumors.

AFFILIATION: 1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Oncogene

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Breast cancer metastases are molecularly distinct from their primary tumors Related Publications

• Adult male replacement and subsequent infant care by male and siblings in socially monogamous owl monkeys (Aotus azarai).
• Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
• Breast cancer metastases are molecularly distinct from their primary tumors.
• Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.
• Endocytic trafficking of rac is required for the spatial restriction of signaling in cell migration.
• Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis.
• Molecular genetic approaches to the study of primate behavior, social organization, and reproduction.
• NUMB controls p53 tumour suppressor activity.
• Playing both sides: nucleophosmin between tumor suppression and oncogenesis.
• Survival prediction of stage I lung adenocarcinomas by expression of 10 genes.
• Unbiased vs. biased approaches to the identification of cancer signatures: the case of lung cancer.
• [News in digestive oncology.]
• [Non-resectable metastases from colorectal cancers]
• [Studies on milk from different species. I. The content of methionine in cow, water buffalo and sheep caseines]