Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice.

Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Research Abstract Details 

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Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Abstract Text:

P X Xing,G Poulos,I F McKenzie,

Mucin-1 (MUC-1), which is overexpressed in more than 90% of human breast cancers, is a potential target for immunotherapy. To develop a mouse model appropriate for the immunotherapy of human cancer, mouse mucin-1 (muc-1) fusion protein, containing ten tandem repeats, was made and used to immunize C3H/HeOuj mice, which supposedly have a high incidence of breast cancer. C3H/HeOuj mice were injected eight times with 5 microg oxidized mannan muc-1-glutathione-S-transferase (MMFP) with or without cyclophosphamide, which is used to increase cellular immunity. At 80 age weeks, only 12.1% (4 of 33) mice of the untreated C3H/HeOuj mice had mammary tumors. The reason for the low incidence of breast cancer in these mice is not known, but all the mammary tumors were MUC-1+ breast adenocarcinomas and were transplantable to C3H/HeOuj mice. The incidence was 11.4% (4 of 35) in mice injected with MMFP: 38.2% (13 of 34) in mice given cyclophosphamide; and 14.3% (2 of 14) in mice treated with glutathione-S-transferase. That is, cyclophosphamide increased the incidence of mammary tumors, and metastases were found in only these mice. Fewer tumors (6 of 34 or 17.6% compared with 13 of 34 or 38.2% with cyclophosphamide only) occurred in the group immunized with MMFP and cyclophosphamide. Mice immunized with MMFP had high levels of muc-1 antibodies and cellular immune responses (the frequency of the precursor of the cytotoxic Tlymphocyte cell was 1 of 40,000 to 1 of 100,000), which were not found in control groups. The occurrence of muc-1 immunity, particularly the presence of large amounts of anti-mucin-1 antibodies, had no effect on tumor incidence. Thus, the immunization with murine muc-1 reduced the tumor incidence in only cyclophosphamide-treated mice and led to strong muc-1 antibody production and to cellular responses. These findings have implications for human tumor immunotherapy in which strong antibody and weak cellular responses are to be expected and, indeed, have been found.

Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Publishing Authors By Initials

PX Xing,G Poulos,IF McKenzie,

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PUBMED ID PMID:

MEDLINE DATE: 2001 Jan-Feb

Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997)

VOLUME: 24

Page Numbers: 10-8

Journal Abbreviation: J. Immunother.

ISSN: 1524-9557

DAY: 1

MONTH: 12

YEAR: 2007

Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9706083

Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Keywords Mesh Terms:

KEYWORDS: Peptide Fragments

MESH TERMS: immunology

Chemical & Substance for Abstract: Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice. Information

Substance Name: Cyclophosphamide

Registry Number: 50-18-0

Grant and Affiliation Information for Breast cancer in mice: effect of murine MUC-1 immunization on tumor incidence in C3H/HeOuj mice.

AFFILIATION: The Austin Research Institute, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia.

Country: United States

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MEDLINETA: J Immunother (1997)

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