Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Abstract Text:

Anupama E Gururaj,Caroline Holm, Landberg,Rakesh Kumar,

Lysine acetylation occurs in many protein targets, including core histones, transcription factors, and other proteins. Metastasis-associated protein 1 (MTA1) is implicated in the progression and metastasis of various epithelial tumors. Because MTA1 functions as a transcriptional coregulator, much of its role in cancer promoting processes are likely to involve its ability to regulate the transcription of downstream target genes that encode effector proteins. We recently showed that MTA1 could be post-translationally modified by acetylation, which modulates its function as a coregulator molecule. We also defined a chromatin target of MTA1, namely, breast cancer-amplified sequence 3 (BCAS3), in the context of which MTA1 behaves as a transcriptional coactivator in breast cancer cells. Because the phenotypic effect of BCAS3 overexpression in tumors has not been defined, we investigated the consequence of increased expression of BCAS3 in human breast tumors. Here, we report that BCAS3 overexpression in hormone receptor-positive premenopausal breast cancer seemed to be associated with impaired responses to tamoxifen. Our findings have implications for endocrine therapy.

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Publishing Authors By Initials

AE Gururaj,C Holm,G Landberg,R Kumar,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 5

Page Numbers: 1407-10

Journal Abbreviation:

ISSN: 1551-4005

DAY: 1

MONTH: 07

YEAR: 2006

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101137841

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.

AFFILIATION: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Cycle

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer Related Publications

• A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas.
• A new paradigm for the treatment of high-risk prostate cancer: radiosensitization with docetaxel.
• An inherent role of microtubule network in the action of nuclear receptor.
• Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude.
• Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.
• Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.
• Cognitive function in adults with type 2 diabetes and major depression.
• Diagnosis and management of extensive vertex birth molding.
• Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
• Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture.
• Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro.
• HPA axis activity and neuropathogenesis in HIV-1 clade C infection.
• How substance use differs among American secondary schools.
• Influence of Agrobacterium rhizogenes Strains on Biomass and Alkaloid Productivity in Hairy Root Lines of Hyoscyamus muticus and H. albus *.
• Letter to the editor: The suckling-micturition reflex in cows.
• Metal-binding properties of human centrin-2 determined by micro-electrospray ionization mass spectrometry and UV spectroscopy.
• Metastasis tumor antigens, an emerging family of multifaceted master coregulators.
• Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
• Modification of the expression of adenosine 3',5'-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate.
• P21-activated kinases in human cancer.
• Pituitary abscess: Report of four cases and review of literature.
• Potential medicinal plants for CNS disorders: an overview.
• Protein disulfide isomerase assisted protein folding in malaria parasites.
• Quality of life in HIV subtype C infection among asymptomatic subjects and its association with CD4 counts and viral loads--a study from South India.
• Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
• Sexual differentiation and development in the malaria parasite.
• Standard wound coverage techniques for extremity war injury.
• Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
• Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.
• p21-activated kinase signaling in breast cancer.