BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Abstract Text:

Gayle J Pageau,Jeanne B Lawrence,

Breast cancer-associated protein 1 (BRCA1) forms foci at sites of induced DNA damage, but any significance of these normal S-phase foci is unknown. BRCA1 distribution does not simply mirror or overlap that of replicating DNA; however, BRCA1 foci frequently abut sites of BrdU incorporation, mostly at mid-to-late S phase. Although BRCA1 does not overlap XIST RNA across the inactive X chromosome, BRCA1 foci position overwhelmingly in heterochromatic regions, particularly the nucleolar periphery where many centromeres reside. In humans and mice, including early embryonic cells, BRCA1 commonly associates with interphase centromere-kinetochore complexes, including pericentric heterochromatin. Proliferating cell nuclear antigen or BrdU labeling demonstrates that BRCA1 localizes adjacent to, or "paints," major satellite blocks as chromocenters replicate, where topoisomerase is also enriched. BRCA1 loss is often associated with proliferative defects, including postmitotic bridges enriched with satellite DNA. These findings implicate BRCA1 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel means whereby BRCA1 loss may contribute to genomic instability and cancer.

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Publishing Authors By Initials

GJ Pageau,JB Lawrence,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research

PUBMED ID PMID:

MEDLINE DATE:

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of cell biology

VOLUME: 175

Page Numbers: 693-701

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 4

MONTH: Dec

YEAR: 2006

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375356

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Keywords Mesh Terms:

KEYWORDS: S Phase

MESH TERMS: metabolism

Chemical & Substance for Abstract: BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Information

Substance Name: Heterochromatin

Registry Number: 0

Grant and Affiliation Information for BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.

AFFILIATION: Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM68138

ACRONYM: GM

MEDLINETA: J Cell Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin Related Publications

• A pilot study of [18F]fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer.
• Acquisition of a "Group A"-selective Src kinase inhibitor via a global targeting strategy.
• An Impulse-Response Model using Pace and Duration Correlates to Performance of a 1500 m Olympic Finalist: 1416: Board #179 May 30 11:00 AM -12:30 PM.
• An evaluation of the seasonality of veterinary treatments for lameness in UK dairy cattle.
• Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.
• Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells.
• BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin.
• BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.
• Central overexpression of angiotensin AT(1A) receptors prevents dopamine D(2) receptor regulation of alcohol consumption in mice.
• Cr04 six year, prospective analysis of rectal bleeding clinics at the queen elizabeth hospital, adelaide, South australia.
• Environmental toxins as modulators of antiviral immune responses.
• Evidence that the Pim1 kinase gene is a direct target of HOXA9.
• Heartbeat perception in depression.
• Housing system, milk production, and zero-grazing effects on lameness and leg injury in dairy cows.
• Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.
• Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
• Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses.
• Light-regulated sampling of protein tyrosine kinase activity.
• Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.
• Open access publication is growing in importance.
• PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
• Propagating uncertainty in microarray data analysis.
• Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response.
• Sterols of Delphinium ajacis; Production and Metabolic Relationships in Whole Plants and Callus Tissue*.
• The Gibbs Centroid Sampler.
• The clinical application of intensity-modulated radiation therapy.
• The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin.
• The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas.
• Twinning in mares: A survey of veterinarians and analyses of theriogenology records.
• Wettability modification and the subsequent manipulation of protein adsorption on a Ti6Al4V alloy by means of CO2 laser surface treatment.