Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis.

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Research Abstract Details 

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Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Abstract Text:

Kumlesh K Dev,Florian Mullershausen,Henri Mattes,Rainer R Kuhn,Graeme Bilbe,Daniel Hoyer,Anis Mir,Kumlesh K Dev,Florian Mullershausen,Henri Mattes,Rainer R Kuhn,Graeme Bilbe,Daniel Hoyer,Anis Mir,

Multiple sclerosis (MS) is an autoimmune, neurological disability with unknown etiology. The current therapies available for MS work by an immunomodulatory action, preventing T-cell- and macrophage-mediated destruction of brain-resident oligodendrocytes and axonal loss. Recently, FTY720 (fingolimod) was shown to significantly reduce relapse rates in MS patients and is currently in Phase III clinical trials. This drug attenuates trafficking of harmful T cells entering the brain by regulating sphingosine-1-phosphate (S1P) receptors. Here, we outline the direct roles that S1P receptors play in the central nervous system (CNS) and discuss additional modalities by which FTY720 may provide direct neuroprotection in MS.

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Publishing Authors By Initials

KK Dev,F Mullershausen,H Mattes,RR Kuhn,G Bilbe,D Hoyer,A Mir,KK Dev,F Mullershausen,H Mattes,RR Kuhn,G Bilbe,D Hoyer,A Mir,

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Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology & therapeutics

VOLUME: 117

Page Numbers: 77-93

Journal Abbreviation: Pharmacol. Ther.

ISSN: 0163-7258

DAY: 8

MONTH: 09

YEAR: 2007

Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis.

AFFILIATION: Department of Anatomy and Neuroscience, University College Cork, Windle Building, Cork, Ireland; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma, Basel, Switzerland.

Country: England

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MEDLINETA: Pharmacol Ther

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