Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder.

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Abstract Text:

Maricel Cabanlit,Sharifia Wills,Paula Goines,Paul Ashwood,Judy Van de Water,

Although autism spectrum disorder (ASD) is diagnosed on the basis of behavioral parameters, several studies have reported immune system abnormalities and suggest the possible role of autoimmunity in the pathogenesis of ASD. In this study we sought to assess the incidence of brain-specific autoantibodies in the plasma of children with autism (AU) compared to age-matched controls including, siblings without ASD, typically developing (TD) controls, and children with other developmental disabilities, but not autism (DD). Plasma from 172 individuals (AU, n = 63, median age: 43 months; TD controls, n = 63, median age: 48 months; siblings, n = 25, median age: 61 months; and DD controls, n = 21, median age: 38 months) was analyzed by Western blot for the presence of IgG antibodies against protein extracts from specific regions of the human adult brain including the hypothalamus and thalamus. The presence of a approximately 52 kDa MW band, in the plasma of subjects with AU, was detected with a significantly higher incidence when compared to plasma from TD controls (29% vs. 8%, P = 0.0027 and 30% vs. 11%, P = 0.01, in the thalamus and hypothalamus, respectively). Reactivity to three brain proteins (42-48 kDa MW), in particular in the hypothalamus, were observed with increased incidence in 37% of subjects with AU compared to 13% TD controls (P = 0.004). Multiple brain-specific autoantibodies are present at significantly higher frequency in children with AU. While the potential role of these autoantibodies in AU is currently unknown, their presence suggests a loss of self-tolerance to one or more neural antigens during early childhood.

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Publishing Authors By Initials

M Cabanlit,S Wills,P Goines,P Ashwood,J Van de Water,

For similar natural sciences: chemistry: chemistry, physical: molecular weight research abstracts see: natural sciences: chemistry: chemistry, physical: molecular weight research

PUBMED ID PMID:

MEDLINE DATE:

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Annals of the New York Academy of Sciences

VOLUME: 1107

Page Numbers: 92-103

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 3

MONTH: Jun

YEAR: 2007

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7506858

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Keywords Mesh Terms:

KEYWORDS: Molecular Weight

MESH TERMS: metabolism

Chemical & Substance for Abstract: Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Information

Substance Name: Autoantibodies

Registry Number: 0

Grant and Affiliation Information for Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder.

AFFILIATION: Division of Rheumatology, Allergy and Clinical Immunology, UC Davis, Davis, CA 95616, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: 1 P01 ES11269-01

ACRONYM: ES

MEDLINETA: Ann N Y Acad Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder Related Publications

• Annexin A2 Phosphorylation Mediates Cell Scattering and Branching Morphogenesis via Cofilin Activation.
• Biopolymer-released dexamethasone prevents tumor necrosis factor alpha-induced loss of auditory hair cells in vitro: implications toward the development of a drug-eluting cochlear implant electrode array.
• Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder.
• Brief Report: Plasma Leptin Levels are Elevated in Autism: Association with Early Onset Phenotype?
• Changing pollen types/concentrations/distribution in the United States: fact or fiction?
• D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.
• Dexamethasone and methylprednisolone do not inhibit neuritic outgrowth while inhibiting outgrowth of fibroblasts from spiral ganglion explants.
• Hic-5 Promotes the Hypertrophic Scar Myofibroblast Phenotype by Regulating the TGF-beta1 Autocrine Loop.
• Identification of the Peptide Sequences within the EIIIA (EDA) Segment of Fibronectin That Mediate Integrin {alpha}9{beta}1-dependent Cellular Activities.
• Local dexamethasone therapy conserves hearing in an animal model of electrode insertion trauma-induced hearing loss.
• Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study.
• Medicare Finances: findings of the 2008 Trustees Report.
• Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro.
• Problems faced by a writer in communicating research findings in child development.
• TGF-beta1 Slows the Growth of Pathogenic Myofibroblasts through a Mechanism Requiring the Focal Adhesion Protein, Hic-5.
• The fibronectin synergy site modulates TGF-beta-dependent fibroblast contraction.
• Turbulence of a free surface.
• Writing in turbulent air.