Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus.

Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Research Abstract Details 

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Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Abstract Text:

A D Gruber,M Hewicker-Trautwein,B Liess,G Trautwein,

A total of six ewes were intravenously inoculated at between 65 and 68 days of gestation with the Indiana strain of bovine viral diarrhoea virus (BVDV), containing both non-cytopathogenic (ncp) and cytopathogenic (cp) biotypes. Eight transplacentally infected fetuses were sequentially removed from the infected ewes and were found to have inflammatory lesions and malformations of the brain. BVDV RNA was isolated from formalin-fixed, paraffin-embedded brain tissue sections and detected by nested polymerase chain reaction after reverse transcription. The two biotypes of BVDV were distinguished by the fact that a sequence insertion in the RNA of the cp biotype of the inoculum results in larger amplicons. Only RNA from cp BVDV was detected in three of the brains removed up to 14 days post-inoculation (p.i.), and no BVDV RNA was detected after more than 14 days p.i. These findings suggest that, in critical phases of development, cp BVDV may transplacentally infect the ovine fetal brain and cause malformations.

Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Publishing Authors By Initials

AD Gruber,M Hewicker-Trautwein,B Liess,G Trautwein,

For similar animal diseases: sheep diseases research abstracts see: animal diseases: sheep diseases research

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Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zentralblatt für Veterinärmedizin. Reihe B. Journa

VOLUME: 42

Page Numbers: 443-7

Journal Abbreviation: Zentralblatt Veterinarmedizin

ISSN: 0514-7166

DAY: 13

MONTH: Sep

YEAR: 1995

Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Information

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LANGUAGE: eng

NlmUniqueID: 331325

Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Keywords Mesh Terms:

KEYWORDS: Sheep Diseases

MESH TERMS: virology

Chemical & Substance for Abstract: Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus. Information

Substance Name: RNA, Viral

Registry Number: 0

Grant and Affiliation Information for Brain malformations in ovine fetuses associated with the cytopathogenic biotype of bovine viral-diarrhoea virus.

AFFILIATION: Institute of Pathology, School of Veterinary Medicine, Hannover, Germany.

Country: GERMANY

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MEDLINETA: Zentralbl Veterinarmed B

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