Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain.

Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. Research Abstract Details 

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Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. Abstract Text:

Jason R Gerstner,Quentin Z Bremer,William M Vander Heyden,Timothy M Lavaute,Jerry C Yin,Charles F Landry,

Brain fatty acid binding protein (Fabp7), which is important in early nervous system development, is expressed in astrocytes and neuronal cell precursors in mature brain. We report here that levels of Fabp7 mRNA in adult murine brain change over a 24 hour period. Unlike Fabp5, a fatty acid binding protein that is expressed widely in various cell types within brain, RNA analysis revealed that Fabp7 mRNA levels were elevated during the light period and lower during dark in brain regions involved in sleep and activity mechanisms. This pattern of Fabp7 mRNA expression was confirmed using in situ hybridization and found to occur throughout the entire brain. Changes in the intracellular distribution of Fabp7 mRNA were also evident over a 24 hour period. Diurnal changes in Fabp7, however, were not found in postnatal day 6 brain, when astrocytes are not yet mature. In contrast, granule cell precursors of the subgranular zone of adult hippocampus did undergo diurnal changes in Fabp7 expression. These changes paralleled oscillations in Fabp7 mRNA throughout the brain suggesting that cell-coordinated signals likely control brain-wide Fabp7 mRNA expression. Immunoblots revealed that Fabp7 protein levels also underwent diurnal changes in abundance, with peak levels occurring in the dark period. Of clock or clock-regulated genes, the synchronized, global cycling pattern of Fabp7 expression is unique and implicates glial cells in the response or modulation of activity and/or circadian rhythms.

Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. Publishing Authors By Initials

JR Gerstner,QZ Bremer,WM Vander Heyden,TM Lavaute,JC Yin,CF Landry,

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Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PLoS ONE

VOLUME: 3

Page Numbers: e1631

Journal Abbreviation: PLoS ONE

ISSN: 1932-6203

DAY: 20

MONTH: 02

YEAR: 2008

Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain. Information

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LANGUAGE: eng

NlmUniqueID: 101285081

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Grant and Affiliation Information for Brain Fatty Acid binding protein (fabp7) is diurnally regulated in astrocytes and hippocampal granule cell precursors in adult rodent brain.

AFFILIATION: Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Country: United States

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