Brain event-related potentials: diagnosing early-stage Alzheimer's disease.

Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Research Abstract Details 

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Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Abstract Text:

Robert M Chapman,Geoffrey H Nowlis,John W McCrary,John A Chapman,Tiffany C Sandoval,Maria D Guillily,Margaret N Gardner,Lindsey A Reilly,

A pattern of components from brain event-related potentials (ERPs) (cognitive non-invasive electrical brain measures) performed well in separating early-stage Alzheimer's disease (AD) subjects from normal-aging control subjects and shows promise for developing a clinical diagnostic for probable AD. A Number-Letter task elicited brain activity related to cognitive processes. In response to the task stimuli, brain activity was recorded as ERPs, whose components were measured by principal components analysis (PCA). The ERP component scores to relevant and irrelevant stimuli were used in discriminant analyses to develop functions that successfully classified individuals as belonging to an early-stage Alzheimer's disease group or a like-aged Control group, with probabilities of an individual belonging to each group. Applying the discriminant function to the developmental half of the data showed 92% of the subjects were correctly classified into either the AD group or the Control group with a sensitivity of 1.00. The two crossvalidation results were good with sensitivities of 0.83 and classification accuracies of 0.75-0.79. P3 and CNV components, as well as other, earlier ERP components, e.g. C145 and the memory "Storage" component, were useful in the discriminant functions.

Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Publishing Authors By Initials

RM Chapman,GH Nowlis,JW McCrary,JA Chapman,TC Sandoval,MD Guillily,MN Gardner,LA Reilly,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 194-201

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 20

MONTH: 01

YEAR: 2006

Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 8100437

Brain event-related potentials: diagnosing early-stage Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

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Grant and Affiliation Information for Brain event-related potentials: diagnosing early-stage Alzheimer's disease.

AFFILIATION: Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, NY 14627, USA. rmc@cvs.rochester.edu

Country: United States

AGENCY: United States NIA

GRANT: R01-AG018880

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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