Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity.

Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Research Abstract Details 

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Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Abstract Text:

Robert H Lipsky,Ann M Marini,Robert H Lipsky,Ann M Marini,

Neurotrophins are critical to the development and maintenance of the mammalian central nervous system. Among them is brain-derived neurotrophic factor (BDNF), whose synthesis and release is targeted by activation of glutamate receptors. Perturbation of this process probably underlies neurodegenerative and psychiatric disorders. A naturally occurring variation in humans, in the form of a common single-nucleotide polymorphism in the pro region of the polypeptide at codon 66 (Val66-->Met), affects processing of the pro-BDNF polypeptide and its activation-dependent release. This variant is associated with differences in the volume of the hippocampal formation and with anxiety and depression-related phenotypes. Convergent findings supporting a role for BDNF in alterations to hippocampal structure and behavior are found in a "humanized" BDNF transgenic mouse. Also, recent human genetic studies have supported a role of BDNF signaling in addictive behaviors by allele-, genotype-, and haplotype-based association of the TrkB gene, which encodes the cognate receptor for BDNF, with alcohol dependence. A better understanding of the influence of BDNF-mediated pathways in cell survival and plasticity will aid in developing new approaches to restoring normal function in disease states.

Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Publishing Authors By Initials

RH Lipsky,AM Marini,RH Lipsky,AM Marini,

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Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1122

Page Numbers: 130-43

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 13

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity.

AFFILIATION: Department of Neurology, Program in Neuroscience, 4301 Jones Bridge Rd., Bethesda, MD 20814. amarini@usuhs.mil.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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