Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients.

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Abstract Text:

Randolph S Marshall,John J Ferrera,Anna Barnes, Xian Zhang,Katherine A O'Brien,Mohamad Chmayssani,Joy Hirsch,Ronald M Lazar,Randolph S Marshall,John J Ferrera,Anna Barnes, Xian Zhang,Katherine A O'Brien,Mohamad Chmayssani,Joy Hirsch,Ronald M Lazar,

BACKGROUND: and objective. Visual restoration therapy is a home-based treatment program intended to expand visual fields of hemianopic patients through repetitive stimulation of the borderzone adjacent to the blind field. We hypothesized that the training itself would induce visual field location-specific changes in the brain's response to stimuli, a phenomenon demonstrated in animal experiments but never in humans with brain injury. METHODS: Six chronic right hemianopic patients underwent functional magnetic resonance imaging (fMRI)-responding to stimuli in the trained visual borderzone versus the nontrained seeing field before and after 1 month of visual restoration therapy. Spatially normalized fMRI time-series data were analyzed in a fixed-effects group analysis comparing blood oxygen level dependent (BOLD) activity in the borderzone versus seeing location at baseline and at 1 month. Percent BOLD change was measured to determine each condition's contribution to the time-by-condition interaction. RESULTS: There was a significant time by condition interaction manifested as increased BOLD activity for borderzone detection relative to seeing detection after the first month of therapy, which correlated with a relative improvement in response times in the borderzone location out-of-scanner. The right inferior and lateral temporal, right dorsolateral frontal, bilateral anterior cingulate, and bilateral basal ganglia showed the greatest response. CONCLUSION: Visual restoration therapy appears to induce an alteration in brain activity associated with a shift of attention from the nontrained seeing field to the trained borderzone. The effect appears to be mediated by the anterior cingulate and dorsolateral frontal cortex in conjunction with other higher order visual areas in the occipitotemporal and middle temporal regions. Demonstration of a visual field-specific training effect on brain activity provides an important starting point for understanding the potential for visual therapy in hemianopia.

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Publishing Authors By Initials

RS Marshall,JJ Ferrera,A Barnes, Xian Zhang,KA O'Brien,M Chmayssani,J Hirsch,RM Lazar,RS Marshall,JJ Ferrera,A Barnes, Xian Zhang,KA O'Brien,M Chmayssani,J Hirsch,RM Lazar,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE: 2008 Mar-Apr

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurorehabilitation and neural repair

VOLUME: 22

Page Numbers: 136-44

Journal Abbreviation:

ISSN: 1545-9683

DAY: 14

MONTH: 08

YEAR: 2007

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892086

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients.

AFFILIATION: Department of Neurology Columbia University Medical Center. rsm2@columbia.edu.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurorehabil Neural Repair

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients Related Publications

• A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity.
• Activating physicians within a hospital emergency plan: a concept whose time has come?
• Age, response complexity, and target consistency in visual search.
• All coronary artery bypass graft surgery patients will benefit from angiotensin-converting enzyme inhibitors.
• Altering the direction of optokinetic head nystagmus: a lesion study and a hypothetical model.
• Analysis of Metallothionein, RCAS1 Immunoreactivity Regarding Immune Cell Concentration in the Endometrium and Tubal Mucosa in Ectopic Pregnancy during the Course of Tubal Rupture.
• Bifunctional role of Rev-erbalpha in adipocyte differentiation.
• Brain activity associated with stimulation therapy of the visual borderzone in hemianopic stroke patients.
• CSF fistula in a patient with Mondini deformity: demonstration by CT cisternography.
• Evidence for intermediate S-states as initial phase in the process of oxygen-evolving complex oxidation.
• How insurers, purchasers, and employers view their need for guidelines: report of Washington Business Group on Health--AHCPR focus groups.
• Insurance status and untreated dental caries in Virginia schoolchildren.
• Lung cancer as a second primary malignant tumor: prognostic values after surgical resection.
• Microfluidic platform with mass spectrometry detection for the analysis of phosphoproteins.
• Migration of an endovascular stent from superior vena cava to the right ventricular outflow tract in a patient with superior vena cava syndrome.
• Neurobehavioral differences in superselective Wada testing with amobarbital versus lidocaine.
• Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.
• Pemphigus acutus treated with antibiotics.
• Peripheral arterial disease in HIV-infected and uninfected women.
• Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness.
• Resistin- and Obesity-associated metabolic diseases.
• Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways.
• Rheumatoid factor and malignant disease.
• The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks.
• The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1.
• The thermodynamic driving force for bone growth and remodelling: a hypothesis.
• [Cancer mortality in smaller regions with different structures and conditions of air quality]
• [Lobectomy performed through a video-assisted mini thoracotomy, as a new technique in our clinical practice.]
• [Prediction of preeclampsia using the integrated test markers]
• [Pregnancy and environment. Influence of the socioeconomic level on prematurity]