Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients.

Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Research Abstract Details 

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Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Abstract Text:

OBJECTIVE: To address the long-standing question of whether patients with Bowen disease are at increased risk of internal malignant neoplasms. PATIENTS: A total of 1147 Danish patients diagnosed between 1978 and 1993 as having Bowen disease at nongenital sites were followed up for 6463 person-years for cancer occurrence up to 16 years after the skin lesion. MAIN OUTCOME MEASURE: Standardized incidence ratios (SIRs)--the ratios of observed-to-expected numbers of cancer--served as measures of relative risk. RESULTS: The observed number of noncutaneous cancers occurring in the cohort (n = 115) was close to expected (n = 103.0) (SIR = 1.1; 95% confidence interval, [CI], 0.9-1.3). However, nonmelanoma skin cancer (SIR = 4.3; 95% CI, 3.5-5.4; n = 83), lip cancer (SIR = 8.2; 95% CI, 2.6-19.1; n = 5), and, among men, leukemia (SIR = 3.2; 95% CI, 1.04-7.5; n = 5) occurred in excess. CONCLUSIONS: Patients with Bowen disease do not appear to constitutionally be at any unusually high general cancer risk. The increased risk of invasive skin and lip cancers is likely due to the common risk factor of UV light.

Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Publishing Authors By Initials

For similar neoplasms: neoplasms by site: skin neoplasms research abstracts see: neoplasms: neoplasms by site: skin neoplasms research

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Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of dermatology

VOLUME: 135

Page Numbers: 790-3

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Jul

YEAR: 1999

Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Keywords Mesh Terms:

KEYWORDS: Skin Neoplasms

MESH TERMS: epidemiology

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Grant and Affiliation Information for Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients.

AFFILIATION: Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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