Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye.

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Abstract Text:

BACKGROUND: Many patients with essential blepharospasm also show dry eye signs and symptoms. Botulinum toxin A is an effective treatment for reducing spasms in these patients. In this investigation, the effect of botulinum toxin A injections on tear function and on the morphology of the ocular surface in patients suffering from blepharospasm in combination with a dry eye syndrome was investigated. METHODS: Botulinum toxin A injections were applied to 16 patients with blepharospasm. All patients complained of dry eye symptoms and had reduced tear break up time values. A subjective questionnaire and ocular examinations including tear break up time, Schirmer test without local anaesthesia, and rose bengal staining were evaluated before, 1 week, 1 month, and 3 months after injection. Impression cytology was performed before, 1 month, and 3 months after botulinum toxin A treatment. RESULTS: Although all patients were relieved of blepharospasm after botulinum toxin injections, only three noticed an improvement in dry eye symptoms. Eight patients noticed no difference and five complained of worsening. Tear break up time was found to be increased 1 week and 1 month after injections. Schirmer test measurements were reduced up to 3 months. Rose bengal staining slightly increased 1 week after injections. Impression cytology showed no definite change in conjunctival cell morphology 1 month and 3 months after botulinum toxin A injections. CONCLUSION: In the patients presented here suffering from blepharospasm and dry eye, botulinum toxin A injections were effective in relieving blepharospasm but were not successful in treating dry eye syndrome.

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Publishing Authors By Initials

For similar fluids and secretions: bodily secretions: tears research abstracts see: fluids and secretions: bodily secretions: tears research

PUBMED ID PMID:

MEDLINE DATE:

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 87

Page Numbers: 54-6

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Jan

YEAR: 2003

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 421041

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Keywords Mesh Terms:

KEYWORDS: Tears

MESH TERMS: secretion

Chemical & Substance for Abstract: Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye. Information

Substance Name: Neuromuscular Agents

Registry Number: 0

Grant and Affiliation Information for Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye.

AFFILIATION: Department of Ophthalmology, Auenbruggerplatz 4, A-8036 Graz, Austria. jutta.horwath@kfunigraz.ac.at

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Ophthalmol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye Related Publications

• Botulinum toxin A treatment in patients suffering from blepharospasm and dry eye.