Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring.

Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Research Abstract Details 

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Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Abstract Text:

AIM: To determine the relative impact of CD4+ T cells and CD8+ T cells in protecting mice against ocular HSV-1 challenge. METHODS: CD4+ T cell knockout mice (CD4-/- mice), CD8+ T cell knockout mice (CD8-/- mice), and mice depleted for CD4+ or CD8+ T cells by antibody (CD4+ depleted and CD8+ depleted mice), were examined for their ability to withstand HSV-1 ocular challenge. The parental mice for both knockout mice were C57BL/6J. RESULTS: These results suggest that: (1) both CD4+ deficient mice (CD4-/- and CD4+ depleted mice) and CD8+ deficient mice (CD8-/-, and CD8+ depleted mice) developed significantly more corneal scarring than their C57BL/6J parental strain; (2) the duration of virus clearance from the eyes of the CD4+ deficient mice was 4 days longer than that of the CD8+ deficient mice; and (3) the severity of corneal scarring in the CD4+ deficient mice was approximately twice that of the CD8+ deficient mice. CONCLUSIONS: It was reported here that: (1) CD4+ and CD8+ T cells were both involved in protection against lethal ocular HSV-1 infection; and (2) CD4+ and CD8+ T cells were both involved in protection against HSV-1 induced corneal scarring.

Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Publishing Authors By Initials

For similar fluids and secretions: bodily secretions: tears research abstracts see: fluids and secretions: bodily secretions: tears research

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Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The British journal of ophthalmology

VOLUME: 84

Page Numbers: 408-12

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Apr

YEAR: 2000

Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Keywords Mesh Terms:

KEYWORDS: Tears

MESH TERMS: virology

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Grant and Affiliation Information for Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring.

AFFILIATION: Ophthalmology Research, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, CA 90048, USA.

Country: ENGLAND

AGENCY: United States NEI

GRANT: EY09224

ACRONYM: EY

MEDLINETA: Br J Ophthalmol

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