Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats.

Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Research Abstract Details 

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Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Abstract Text:

M Hosoya,Y Maruoka,M Oda,I Asahina,S Ichinose,K Omura,

Here we report that successful bone formation with a vascular flap inside a cylindrical mold was induced from fat tissue with the use of recombinant human bone morphogenetic protein-2 in rats. Fat tissue connected to blood vessels was prepared to fit into the mold and implanted intramuscularly into the hind leg in Wistar rats. RhBMP-2 (20 micro g) was applied in a collagen sheet previously placed on the inside surface of the mold. Bone formation was confirmed radiologically and morphologically at 2, 4, and 8 weeks after the surgery. In the control group without rhBMP-2 or the group with ligation of the blood vessels before the implantation, bone formation was not observed. Our success in bone formation having a definite size, shape, and blood supply may lead to a therapeutic approach to effective bone reconstitution. The present study is the first report on bone induction from fat tissue by rhBMP-2 in vivo.

Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Publishing Authors By Initials

M Hosoya,Y Maruoka,M Oda,I Asahina,S Ichinose,K Omura,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of dental research

VOLUME: 82

Page Numbers: 581-4

Journal Abbreviation: J. Dent. Res.

ISSN: 0022-0345

DAY: 19

MONTH: Aug

YEAR: 2003

Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Information

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LANGUAGE: eng

NlmUniqueID: 354343

Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Bone with a vascular flap induced from fat tissue with the use of rhBMP-2 in rats.

AFFILIATION: Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo 113-8549, Japan.

Country: United States

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MEDLINETA: J Dent Res

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