Bone tissue compositional differences in women with and without osteoporotic fracture.

Bone tissue compositional differences in women with and without osteoporotic fracture. Research Abstract Details 

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Bone tissue compositional differences in women with and without osteoporotic fracture. Abstract Text:

Barbara R McCreadie,Michael D Morris,Tso-Ching Chen,D Sudhaker Rao,William F Finney,Effendi Widjaja,Steven A Goldstein,

It is generally accepted that the hallmark of osteoporosis is a reduction in bone mass. There is significant overlap, however, in bone mineral density between osteoporotic and normal individuals. This study examined the chemical composition of bone tissue obtained from women who had sustained a fracture and women without fracture to determine if there are differences between the two groups. Nineteen fractured and eleven non-fractured proximal femurs were obtained, matched for age and bone volume fraction obtained from micro-computed tomography. Trabecular bone specimens were examined by Raman spectroscopy to determine measures of chemical composition. A subset of the specimens was utilized to compare locations at the fracture and regions at least 2 mm away from apparent tissue damage using Raman spectroscopy. In addition, fifteen iliac crest biopsies each were obtained from women who had sustained a fracture and from normal controls. Raman spectroscopy was used to determine measures of chemical composition of trabecular and cortical bone. The results demonstrated that femoral bone tissue in the region of visible damage had a trend towards differences compared to regions at least 2 mm from visible damage. Femoral trabecular bone in fractured women had a higher carbonate/amide I area ratio than in unfractured women. Iliac crest biopsies revealed a higher carbonate/phosphate ratio in cortical bone from women who had sustained a fracture. Results suggest that the chemical composition of bone tissue may be an additional risk factor for osteoporotic fracture.

Bone tissue compositional differences in women with and without osteoporotic fracture. Publishing Authors By Initials

BR McCreadie,MD Morris,TC Chen,D Sudhaker Rao,WF Finney,E Widjaja,SA Goldstein,

For similar investigative techniques: chemistry, analytical: scattering, radiation: spectrum analysis, raman research abstracts see: investigative techniques: chemistry, analytical: scattering, radiation: spectrum analysis, raman research

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Bone tissue compositional differences in women with and without osteoporotic fracture. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bone

VOLUME: 39

Page Numbers: 1190-5

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 9

MONTH: 08

YEAR: 2006

Bone tissue compositional differences in women with and without osteoporotic fracture. Information

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LANGUAGE: eng

NlmUniqueID: 8504048

Bone tissue compositional differences in women with and without osteoporotic fracture. Keywords Mesh Terms:

KEYWORDS: Spectrum Analysis, Raman

MESH TERMS: metabolism

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Grant and Affiliation Information for Bone tissue compositional differences in women with and without osteoporotic fracture.

AFFILIATION: Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, University of Michigan, 2015 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. riemer@umich.edu

Country: United States

AGENCY: United States NIAMS

GRANT: AR47969

ACRONYM: AR

MEDLINETA: Bone

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