Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers.

Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Research Abstract Details 

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Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Abstract Text:

Oneida A Arosarena,Wesley L Collins,

OBJECTIVE: To compare mandibular bone regeneration with bone morphogenetic protein-2 (BMP-2) delivered with two carriers: a hyaluronic acid polymer (HY), and a collagen carrier complexed with calcium hydroxyapatite and tricalcium phosphate (collagen/HA/TCP). STUDY DESIGN: Defects were created in the bilateral mandibular bodies of 16 Sprague-Dawley rats. The defects were filled with the HY carrier, the HY carrier loaded with BMP-2, the collagen/HA/TCP carrier, or the collagen/HA/TCP carrier loaded with BMP-2. Animals were euthanatized after 6 weeks, and the hemi-mandibles were analyzed histomorphologically. RESULTS: Specimens containing BMP-2 had significantly larger new bone and marrow volumes than control specimens. Specimens in the hyaluronan/BMP-2 group tended to have larger volumes of new bone and osteoid than collagen/HA/TCP/BMP-2 specimens, though these differences were not statistically significant. CONCLUSION: The HY and collagen/HA/TCP carriers had comparable efficacy for bone healing with BMP-2. SIGNIFICANCE: Bone morphogenetic proteins can be delivered with commercially available alloplasts as osteogenic bone substitutes for the repair of craniofacial bone defects. EBM rating: B-2.

Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Publishing Authors By Initials

OA Arosarena,WL Collins,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Otolaryngology--head and neck surgery : official j

VOLUME: 132

Page Numbers: 592-7

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ISSN: 0194-5998

DAY: 19

MONTH: Apr

YEAR: 2005

Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Information

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LANGUAGE: eng

NlmUniqueID: 8508176

Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers.

AFFILIATION: Division of Otolaryngology, Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Room C236, Lexington, KY 40536-0293, USA. oaaros2@pop.uky.edu

Country: United States

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MEDLINETA: Otolaryngol Head Neck Surg

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