Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.

Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Research Abstract Details 

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Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Abstract Text:

Chiharu Kawamura,Masahiro Kizaki,Yasuo Ikeda,

BMPs (bone morphogenetic proteins), members of the transforming growth factor (TGF)-beta superfamily, are a group of related proteins which are capable of inducing the formation of cartilage and bone, but are now regarded as multifunctional cytokines. However, little is known about their role in hematopoiesis. Recently, we found a novel function of BMPs to hematopoietic cells in that BMP-2 induces apoptosis not only in human myeloma cell lines, but also in primary samples from patients with multiple myeloma in vitro. BMP-2 caused cell cycle arrest in the G1 phase which was associated with accumulation of p21CIP1/WAF1 and p27KIP1, and the subsequent apoptosis of myeloma cells. Further analysis showed that BMP-2 induced down-regulation of Bcl-X(L) through the inactivation of STAT3, resulting in the induction of apoptosis in myeloma cells. We conclude that BMP-2 may have the potential to be one of the novel therapeutic agents for treatment in patients with multiple myeloma because of the beneficial effects on both myeloma cells and bone diseases. In this review, we summarize data concerning BMPs and BMP-2-induced apoptosis of myeloma cells including our own recent experimental data.

Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Publishing Authors By Initials

C Kawamura,M Kizaki,Y Ikeda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Journal Published:

PUBLICATION TYPE: Review

Journal: Leukemia & lymphoma

VOLUME: 43

Page Numbers: 635-9

Journal Abbreviation: Leuk. Lymphoma

ISSN: 1042-8194

DAY: 19

MONTH: Mar

YEAR: 2002

Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Information

Number of References: 48

LANGUAGE: eng

NlmUniqueID: 9007422

Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Information

Substance Name: Bone Morphogenetic Protein Receptors

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.

AFFILIATION: Division of Hematology, Keio University School of Medicine, Tokyo, Japan.

Country: Switzerland

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MEDLINETA: Leuk Lymphoma

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