Bone morphogenetic protein-3 is a negative regulator of bone density.

Bone morphogenetic protein-3 is a negative regulator of bone density. Research Abstract Details 

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Bone morphogenetic protein-3 is a negative regulator of bone density. Abstract Text:

A Daluiski,T Engstrand,M E Bahamonde,L W Gamer,E Agius,S L Stevenson,K Cox,V Rosen,K M Lyons,A Daluiski,T Engstrand,M E Bahamonde,L W Gamer,E Agius,S L Stevenson,K Cox,V Rosen,K M Lyons,

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-beta) superfamily. Many BMPs are produced in bone and show osteogenic activity, suggesting that they may be determinants of bone mass. BMP3 was originally purified from bone as osteogenin, which induces osteogenic differentiation. Recombinant BMP3 (rhBMP3) has no biological activity, however, leaving its role in skeletal growth unclear. Here we show that BMP3 is an antagonist of osteogenic BMPs: BMP3 dorsalizes Xenopus laevis embryos, inhibits BMP2-mediated induction of Msx2 and blocks BMP2-mediated differentiation of osteoprogenitor cells into osteoblasts. These effects appear to be mediated through activin receptors. Finally, Bmp3(-/-) mice have twice as much trabecular bone as wild-type littermates, indicating that BMP3, the most abundant BMP in adult bone, is a negative determinant of bone density.

Bone morphogenetic protein-3 is a negative regulator of bone density. Publishing Authors By Initials

A Daluiski,T Engstrand,ME Bahamonde,LW Gamer,E Agius,SL Stevenson,K Cox,V Rosen,KM Lyons,A Daluiski,T Engstrand,ME Bahamonde,LW Gamer,E Agius,SL Stevenson,K Cox,V Rosen,KM Lyons,

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research

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Bone morphogenetic protein-3 is a negative regulator of bone density. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature genetics

VOLUME: 27

Page Numbers: 84-8

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 19

MONTH: Jan

YEAR: 2001

Bone morphogenetic protein-3 is a negative regulator of bone density. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216904

Bone morphogenetic protein-3 is a negative regulator of bone density. Keywords Mesh Terms:

KEYWORDS: Xenopus laevis

MESH TERMS: embryology

Chemical & Substance for Abstract: Bone morphogenetic protein-3 is a negative regulator of bone density. Information

Substance Name: Activin Receptors

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Bone morphogenetic protein-3 is a negative regulator of bone density.

AFFILIATION: Department of Orthopaedic Surgery, University of California, Los Angeles, California, USA.

Country: UNITED STATES

AGENCY: United States NIAMS

GRANT: AR44528

ACRONYM: AR

MEDLINETA: Nat Genet

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