Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice.

Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Research Abstract Details 

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Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Abstract Text:

Satoru Otsuru,Katsuto Tamai,Takehiko Yamazaki,Hideki Yoshikawa,Yasufumi Kaneda,

Recent studies have suggested the existence of osteoblastic cells in the circulation, but the origin and role of these cells in vivo are not clear. Here, we examined how these cells contribute to osteogenesis in a bone morphogenetic protein (BMP)-induced model of ectopic bone formation. Following lethal dose-irradiation and subsequent green fluorescent protein-transgenic bone marrow cell-transplantation (GFP-BMT) in mice, a BMP-2-containing collagen pellet was implanted into muscle. Three weeks later, a significant number of GFP-positive osteoblastic cells were present in the newly generated ectopic bone. Moreover, peripheral blood mononuclear cells (PBMNCs) from the BMP-2-implanted mouse were then shown to include osteoblast progenitor cells (OPCs) in culture. Passive transfer of the PBMNCs isolated from the BMP-2-implanted GFP-mouse to the BMP-2-implanted nude mouse led to GFP-positive osteoblast accumulation in the ectopic bone. These data provide new insight into the mechanism of ectopic bone formation involving bone marrow-derived OPCs in circulating blood.

Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Publishing Authors By Initials

S Otsuru,K Tamai,T Yamazaki,H Yoshikawa,Y Kaneda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 354

Page Numbers: 453-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 10

MONTH: 01

YEAR: 2007

Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Information

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LANGUAGE: eng

NlmUniqueID: 372516

Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice.

AFFILIATION: Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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