Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes.

Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Research Abstract Details 

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Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Abstract Text:

Michael J F Blumer,Stefano Longato,Christoph Schwarzer,Helga Fritsch,

In mammals, the exact role of cartilage canals is still under discussion. Therefore, we studied their development in the distal femoral epiphysis of mice to define the importance of these canals. Various approaches were performed to examine the histological, cellular, and molecular events leading to bone formation. Cartilage canals started off as invaginations of the perichondrium at day (D) 5 after birth. At D 10, several small ossification nuclei originated around the canal branched endings. Finally, these nuclei coalesced and at D 18 a large secondary ossification centre (SOC) occupied the whole epiphysis. Cartilage canal cells expressed type I collagen, a major bone-relevant protein. During canal formation, several resting chondrocytes immediately around the canals were active caspase 3 positive but others were freed into the canal cavity and appeared to remain viable. We suggest that cartilage canal cells belong to the bone lineage and, hence, they contribute to the formation of the bony epiphysis. Several resting chondrocytes are assigned to die but others, after freeing into the canal cavity, may differentiate into osteoblasts.

Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Publishing Authors By Initials

MJ Blumer,S Longato,C Schwarzer,H Fritsch,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research

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Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 2077-88

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 28

MONTH: Aug

YEAR: 2007

Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Information

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LANGUAGE: eng

NlmUniqueID: 9201927

Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Keywords Mesh Terms:

KEYWORDS: Mice

MESH TERMS: physiology

Chemical & Substance for Abstract: Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Information

Substance Name: F 0401

Registry Number: 123852-99-3

Grant and Affiliation Information for Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes.

AFFILIATION: Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Innsbruck Medical University, Innsbruck, Austria. michael.blumer@i-med.ac.at

Country: United States

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MEDLINETA: Dev Dyn

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