Bone-derived factors active on bone cells.

Bone-derived factors active on bone cells. Research Abstract Details 

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Bone-derived factors active on bone cells. Abstract Text:

S Mohan,T Linkhart,J Farley,D Baylink,

Effects of systemic calcium regulating hormones have been studied extensively, yet mechanisms of bone volume regulation at the local level are poorly understood. Our laboratory has reported evidence for two locally mediated processes of bone volume regulation which function independently of systemic control: (1) coupling of bone formation and resorption and (2) repletion of resorbed bone. These local regulatory mechanisms have been shown to occur in vivo and in vitro. We have reported that embryonic chick tibiae in culture, stimulated to resorb, release a factor in the serum-free culture medium that stimulates bone cell proliferation and bone matrix formation in vitro. We have postulated that this factor could be involved in the coupling mechanism. Subsequently, a similar factor which stimulates bone cell proliferation, collagen synthesis and bone formation in vitro was extracted from embryonic and adult bones. The factor partially purified from human bone, designated as human skeletal growth factor, has molecular weight, heat sensitivity and biological activity similar to the factor found in bone conditioned medium. Many other biologically active factors have also been extracted from bone cells or demineralized bone by different laboratories. Their actions on bone cells range from chemotactic to mitogenic. These recently discovered bone factors emphasize that there is important regulation of bone metabolism at the local level.

Bone-derived factors active on bone cells. Publishing Authors By Initials

S Mohan,T Linkhart,J Farley,D Baylink,

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Bone-derived factors active on bone cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Calcified tissue international

VOLUME: 36 Suppl 1

Page Numbers: S139-45

Journal Abbreviation: Calcif. Tissue Int.

ISSN: 0171-967X

DAY: 18

MONTH: 01

YEAR: 1984

Bone-derived factors active on bone cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905481

Bone-derived factors active on bone cells. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Bone-derived factors active on bone cells. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Bone-derived factors active on bone cells.

AFFILIATION:

Country: GERMANY, WEST

AGENCY: United States NIADDK

GRANT: AM 31062

ACRONYM: AM

MEDLINETA: Calcif Tissue Int

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