BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction.

BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Research Abstract Details 

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BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Abstract Text:

Arjang Djamali,Elizabeth A Sadowski,Rebecca J Muehrer,Shannon Reese,Chanigan Smavatkul,Aparna Vidyasagar,Sean B Fain,Ryan C Lipscomb,Debra H Hullett,Millie Samaniego-Picota,Thomas M Grist,Bryan N Becker,

Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) uses deoxyhemoglobin as an endogenous contrast agent for the noninvasive assessment of tissue oxygen bioavailability. We hypothesized that intrarenal oxygenation was impaired in patients with chronic allograft nephropathy (CAN). Ten kidney-transplant recipients with CAN and nine healthy volunteers underwent BOLD-MRI. Medullary R2* (MR2*) and cortical R2* (CR2*) levels (measures directly proportional to tissue deoxyhemoglobin levels) were determined alongside urine and serum markers of oxidative stress (OS): hydrogen peroxide (H(2)O(2)), F(2)-isoprostanes, total nitric oxide (NO), heat shock protein 27 (HSP27), and total antioxidant property (TAOP). Mean MR2* and CR2* levels were significantly decreased in CAN (increased local oxyhemoglobin concentration) compared with healthy volunteers (20.7 +/- 1.6 vs. 23.1 +/- 1.8/s, P = 0.03 and 15.9 +/- 1.9 vs. 13.6 +/- 2.3/s, P = 0.05, respectively). There was a significant increase in serum and urine levels of H(2)O(2) and serum HSP27 levels in patients with CAN. Conversely, urine NO levels and TAOP were significantly increased in healthy volunteers. Multiple linear regression analyses showed a significant association between MR2* and CR2* levels and serum/urine biomarkers of OS. BOLD-MRI demonstrated significant changes in medullary and cortical oxygen bioavailability in allografts with CAN. These correlated with serum/urine biomarkers of OS, suggesting an association between intrarenal oxygenation and OS.

BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Publishing Authors By Initials

A Djamali,EA Sadowski,RJ Muehrer,S Reese,C Smavatkul,A Vidyasagar,SB Fain,RC Lipscomb,DH Hullett,M Samaniego-Picota,TM Grist,BN Becker,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

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BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F513-22

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 24

MONTH: 10

YEAR: 2006

BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Information

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LANGUAGE: eng

NlmUniqueID: 100901990

BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: urine

Chemical & Substance for Abstract: BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Information

Substance Name: deoxyhemoglobin

Registry Number: 9008-02-0

Grant and Affiliation Information for BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction.

AFFILIATION: Department of Medicine, University of Wisconsin-Madison, Madison, WI 53713, USA. axd@medicine.wisc.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R21/R33 DK-070243-01

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

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