Body fat and circulating leukocytes in children.

Body fat and circulating leukocytes in children. Research Abstract Details 

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Body fat and circulating leukocytes in children. Abstract Text:

F Zaldivar,R G McMurray,D Nemet,P Galassetti,P J Mills,D M Cooper,

OBJECTIVE: To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. DESIGN: Two group comparison of leukocytes in normal weight control and overweight children.Subjects:In total, 38 boys and girls, ages 6-18 years, divided in two groups: normal weight, (NW, BMI<85th %tile, n=15) and overweight (OW, body mass index (BMI)>85th %tile, n=23). MEASUREMENTS: BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. Complete blood counts (CBC) were obtained by standard clinical hematology methods and surface antigen staining by flow cytometry. RESULTS: The OW group compared to the NW group had increased total leukocytes counts (P=0.011), neutrophils (P=0.006), monocytes (P=0.008), total T (CD3) lymphocytes (P=0.022), and Helper T (CD4(+)) cells (P=0.003). Significant correlations were evident between leukocytes, and BMI percentile, BMI, or percent body fat. Neither lean body mass nor VO(2peak) per unit lean body mass were significantly related to any of the leukocytes. Percent body fat and BMI percentile were positively correlated (P<0.05) to total T cells (CD3) and/or helper T cells (CD4(+)). CONCLUSION: A group of 23 overweight children displayed elevated counts in most types of circulating immune cells, suggesting the presence of low-grade systemic inflammation, a known pathogenetic mechanism underlying most long-term complications of obesity. Our data provide an additional rationale for the importance of avoiding or correcting pediatric obesity.

Body fat and circulating leukocytes in children. Publishing Authors By Initials

F Zaldivar,RG McMurray,D Nemet,P Galassetti,PJ Mills,DM Cooper,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: lymphocyte subsets: t-lymphocyte subsets research

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Body fat and circulating leukocytes in children. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of obesity (2005)

VOLUME: 30

Page Numbers: 906-11

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ISSN: 0307-0565

DAY: 3

MONTH: Jun

YEAR: 2006

Body fat and circulating leukocytes in children. Information

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LANGUAGE: eng

NlmUniqueID: 101256108

Body fat and circulating leukocytes in children. Keywords Mesh Terms:

KEYWORDS: T-Lymphocyte Subsets

MESH TERMS: immunology

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Grant and Affiliation Information for Body fat and circulating leukocytes in children.

AFFILIATION: Pediatric Exercise Research Center, University of California, Irvine, CA, USA.

Country: England

AGENCY: United States NHLBI

GRANT: R01-HL08947

ACRONYM: HL

MEDLINETA: Int J Obes (Lond)

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