BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses.

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Research Abstract Details 

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BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Abstract Text:

Cornelia Brunner,Anca Sindrilaru,Irute Girkontaite,Klaus-Dieter Fischer,Cord ,Thomas Wirth,

BOB.1/OBF.1 is a transcriptional coactivator essential at several stages of B-cell development. In T cells, BOB.1/OBF.1 expression is inducible by co-stimulation. However, a defined role of BOB.1/OBF.1 for T-cell function had not been discovered so far. Here, we show that BOB.1/OBF.1 is critical for T helper cell function. BOB.1/OBF.1(-/-) mice showed imbalanced immune responses, resulting in increased susceptibility to Leishmania major infection. Functional analyses revealed specific defects in TH1 and TH2 cells. Whereas expression levels of TH1 cytokines were reduced, the secretion of TH2 cytokines was increased. BOB.1/OBF.1 directly contributes to the IFNgamma and IL2 promoter activities. In contrast, increased TH2 cytokine production is controlled indirectly, probably via the transcription factor PU.1, the expression of which is regulated by BOB.1/OBF.1. Thus, BOB.1/OBF.1 regulates the balance of TH1 versus TH2 mediated immunity.

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Publishing Authors By Initials

C Brunner,A Sindrilaru,I Girkontaite,KD Fischer,C ,T Wirth,

For similar proteins: dna-binding proteins: trans-activators research abstracts see: proteins: dna-binding proteins: trans-activators research

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BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 26

Page Numbers: 3191-202

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 14

MONTH: 06

YEAR: 2007

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Keywords Mesh Terms:

KEYWORDS: Trans-Activators

MESH TERMS: metabolism

Chemical & Substance for Abstract: BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses. Information

Substance Name: proto-oncogene protein Spi-1

Registry Number: 0

Grant and Affiliation Information for BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses.

AFFILIATION: Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.

Country: England

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MEDLINETA: EMBO J

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