BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways.

BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Research Abstract Details 

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BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Abstract Text:

T D Piscione,T Phan,N D Rosenblum,

Bone morphogenetic protein-7 (BMP7) controls ureteric bud and collecting duct morphogenesis in a dose-dependent manner (Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisono L, Wrana JL, and Rosenblum ND. Am J Physiol Renal Physiol 273: F961-F975, 1997). We defined cellular and molecular mechanisms underlying these effects in embryonic kidney explants and in the mIMCD-3 cell model of collecting tubule morphogenesis. Low-dose (0.25 nM) BMP7 significantly increased tubule number and cell proliferation. Similar to BMP2, high-dose (10 nM) BMP7 inhibited cell proliferation and stimulated apoptosis. To define molecular mechanisms, we identified signaling events downstream of BMP7. High-dose BMP7, but not low-dose BMP7, activated Smad1 in mIMCD-3 cells. Moreover, the inhibitory effects of high-dose BMP7 and BMP2, but not the stimulatory effects of low-dose BMP7, on tubulogenesis and cell proliferation were significantly reduced in mIMCD-3 cells stably expressing Smad1(Delta458), a dominant negative mutant form of Smad1, but not in cells stably expressing wild-type Smad1. We conclude that BMP7 exerts dose-dependent effects on ureteric bud or collecting duct cell proliferation and apoptosis by signaling via Smad1-dependent and Smad1-independent pathways.

BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Publishing Authors By Initials

TD Piscione,T Phan,ND Rosenblum,

For similar urogenital system: urinary tract: ureter research abstracts see: urogenital system: urinary tract: ureter research

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BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Renal physiology

VOLUME: 280

Page Numbers: F19-33

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 19

MONTH: Jan

YEAR: 2001

BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Information

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LANGUAGE: eng

NlmUniqueID: 100901990

BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Keywords Mesh Terms:

KEYWORDS: Ureter

MESH TERMS: embryology

Chemical & Substance for Abstract: BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways.

AFFILIATION: Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8.

Country: UNITED STATES

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MEDLINETA: Am J Physiol Renal Physiol

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