Bmp2 is critical for the murine uterine decidual response.

Bmp2 is critical for the murine uterine decidual response. Research Abstract Details 

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Bmp2 is critical for the murine uterine decidual response. Abstract Text:

Kevin Y Lee,Jae-Wook Jeong,Jinrong Wang,Lijiang Ma,James F Martin,Sophia Y Tsai,John P Lydon,Francesco J DeMayo,

The process of implantation, necessary for all viviparous birth, consists of tightly regulated events, including apposition of the blastocyst, attachment to the uterine lumen, and differentiation of the uterine stroma. In rodents and primates the uterine stroma undergoes a process called decidualization. Decidualization, the process by which the uterine endometrial stroma proliferates and differentiates into large epithelioid decidual cells, is critical to the establishment of fetal-maternal communication and the progression of implantation. The role of bone morphogenetic protein 2 (Bmp2) in regulating the transformation of the uterine stroma during embryo implantation in the mouse was investigated by the conditional ablation of Bmp2 in the uterus using the (PR-cre) mouse. Bmp2 gene ablation was confirmed by real-time PCR analysis in the PR-cre; Bmp2fl/fl (termed Bmp2d/d) uterus. While littermate controls average 0.9 litter of 6.2+/-0.7 pups per month, Bmp2d/d females are completely infertile. Analysis of the infertility indicates that whereas embryo attachment is normal in the Bmp2d/d as in control mice, the uterine stroma is incapable of undergoing the decidual reaction to support further embryonic development. Recombinant human BMP2 can partially rescue the decidual response, suggesting that the observed phenotypes are not due to a developmental consequence of Bmp2 ablation. Microarray analysis demonstrates that ablation of Bmp2 leads to specific gene changes, including disruption of the Wnt signaling pathway, Progesterone receptor (PR) signaling, and the induction of prostaglandin synthase 2 (Ptgs2). Taken together, these data demonstrate that Bmp2 is a critical regulator of gene expression and function in the murine uterus.

Bmp2 is critical for the murine uterine decidual response. Publishing Authors By Initials

KY Lee,JW Jeong,J Wang,L Ma,JF Martin,SY Tsai,JP Lydon,FJ DeMayo,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

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Bmp2 is critical for the murine uterine decidual response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 5468-78

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 21

MONTH: 05

YEAR: 2007

Bmp2 is critical for the murine uterine decidual response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109087

Bmp2 is critical for the murine uterine decidual response. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Bmp2 is critical for the murine uterine decidual response. Information

Substance Name: Tacrolimus Binding Proteins

Registry Number: EC 5.2.1.-

Grant and Affiliation Information for Bmp2 is critical for the murine uterine decidual response.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NICHD

GRANT: U01HD042311

ACRONYM: HD

MEDLINETA: Mol Cell Biol

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