BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Abstract Text:

Kunikazu Tsuji,Amitabha Bandyopadhyay,Brian D Harfe,Karen Cox,Sanjeev Kakar,Louis Gerstenfeld,Thomas Einhorn,Clifford J Tabin,Vicki Rosen,

Adult bones have a notable regenerative capacity. Over 40 years ago, an intrinsic activity capable of initiating this reparative response was found to reside within bone itself, and the term bone morphogenetic protein (BMP) was coined to describe the molecules responsible for it. A family of BMP proteins was subsequently identified, but no individual BMP has been shown to be the initiator of the endogenous bone repair response. Here we demonstrate that BMP2 is a necessary component of the signaling cascade that governs fracture repair. Mice lacking the ability to produce BMP2 in their limb bones have spontaneous fractures that do not resolve with time. In fact, in bones lacking BMP2, the earliest steps of fracture healing seem to be blocked. Although other osteogenic stimuli are still present in the limb skeleton of BMP2-deficient mice, they cannot compensate for the absence of BMP2. Collectively, our results identify BMP2 as an endogenous mediator necessary for fracture repair.

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Publishing Authors By Initials

K Tsuji,A Bandyopadhyay,BD Harfe,K Cox,S Kakar,L Gerstenfeld,T Einhorn,CJ Tabin,V Rosen,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature genetics

VOLUME: 38

Page Numbers: 1424-9

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 12

MONTH: 11

YEAR: 2006

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216904

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: physiology

Chemical & Substance for Abstract: BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

AFFILIATION: Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nat Genet

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing Related Publications

• A 29-year-old man with subcutaneous emphysema of the neck following blunt trauma.
• A web portal that enables collaborative use of advanced medical image processing and informatics tools through the Biomedical Informatics Research Network (BIRN).
• Acute rejection in HCV-infected liver transplant recipients: The great conundrum.
• Are stem cells drugs? The regulation of stem cell research and development.
• ArsD residues Cys12, Cys13, and Cys18 form an As(III)-binding site required for arsenic metallochaperone activity.
• BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.
• Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair.
• Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.
• Diagnosis and management of laryngopharyngeal reflux disease.
• Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.
• Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.
• Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
• Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases.
• Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8.
• Hetereogeneity in skeletal response to full-length parathyroid hormone in the treatment of osteoporosis.
• I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory.
• Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
• Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line.
• Integration is as essential as balance.
• Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.
• Linking cost sharing to value: an unrivaled yet unrealized public health opportunity.
• Long-term cardiac memory in canine heart is associated with the evolution of a transmural repolarization gradient.
• Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence.
• Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
• Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases.
• Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
• Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.
• Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating.
• Sulfated L-selectin ligands as a therapeutic target in chronic inflammation.
• The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2.