BMP and FGF regulatory pathways in semilunar valve precursor cells.

BMP and FGF regulatory pathways in semilunar valve precursor cells. Research Abstract Details 

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BMP and FGF regulatory pathways in semilunar valve precursor cells. Abstract Text:

Bin Zhao,Laura Etter,Robert B Hinton,D Woodrow Benson,

In the developing atrioventricular (AV) valve, limb bud, and somites, cartilage cell lineage differentiation is regulated by bone morphogenetic protein (BMP), while fibroblast growth factor (FGF) controls tendon cell fate. We observed aggrecan and sox9, characteristic of cartilage cell types, and scleraxis and tenascin, characteristic of tendon cell types, in developing avian semilunar valves. Addition of BMP4 to outflow tract (OFT) precursor cells of young (E4.5) but not older (E6) chick embryos activated Smad1/5/8 and induced sox9 and aggrecan expression, while FGF4 treatment increased phosphorylated MAPK (dpERK) signaling and promoted expression of scleraxis and tenascin. These results identify BMP and FGF pathways that promote expression of cartilage- or tendon-like characteristics in semilunar valve precursor cells. In contrast to AV valve precursor cells, which diversify into leaflets (cartilage-like) or chordae tendineae (tendon-like), semilunar valve cells exhibit both cartilage- and tendon-like characteristics in the developing and mature valve cusp.

BMP and FGF regulatory pathways in semilunar valve precursor cells. Publishing Authors By Initials

B Zhao,L Etter,RB Hinton,DW Benson,

For similar musculoskeletal system: tendons research abstracts see: musculoskeletal system: tendons research

PUBMED ID PMID:

MEDLINE DATE:

BMP and FGF regulatory pathways in semilunar valve precursor cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 971-80

Journal Abbreviation:

ISSN: 1058-8388

DAY: 3

MONTH: Apr

YEAR: 2007

BMP and FGF regulatory pathways in semilunar valve precursor cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

BMP and FGF regulatory pathways in semilunar valve precursor cells. Keywords Mesh Terms:

KEYWORDS: Tendons

MESH TERMS: metabolism

Chemical & Substance for Abstract: BMP and FGF regulatory pathways in semilunar valve precursor cells. Information

Substance Name: Fibroblast Growth Factors

Registry Number: 62031-54-3

Grant and Affiliation Information for BMP and FGF regulatory pathways in semilunar valve precursor cells.

AFFILIATION: Division of Cardiology, MLC 7042, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL085122

ACRONYM: HL

MEDLINETA: Dev Dyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

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