BMP-2 decreases Mash1 stability by increasing Id1 expression.

BMP-2 decreases Mash1 stability by increasing Id1 expression. Research Abstract Details 

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BMP-2 decreases Mash1 stability by increasing Id1 expression. Abstract Text:

Francesc ,Julia Reiriz,Santiago Ambrosio,Ramon Bartrons,Jose Luis Rosa,Francesc Ventura,

In neural development, bone morphogenetic proteins (BMPs) restrict neuronal differentiation, thereby promoting the maintenance of progenitor cells or even inducing astrocytogenesis. We report that exposure of neuroendocrine lung carcinoma cells to BMP-2 leads to a rapid decline in steady-state levels of Mash1 protein and some neuron-specific markers. BMP-2 induces a post-transcriptional decrease in Mash1 levels through enhanced degradation. We demonstrate that Mash1 protein stability is tightly regulated by the E47/Id1 expression ratio. Transient induction of Id1 by BMP-2 negatively correlates with Mash1 levels. Furthermore, an ectopic increase in Id1 levels is sufficient to induce degradation of either ectopic or endogenous Mash1, whereas expression of Mash1 in Id1-deficient cells or overexpression of E47 makes Mash1 levels refractory to the addition of BMP-2. Furthermore, we show that the E47/Id1 expression ratio also regulates CK2-mediated phosphorylation of Mash1 on Ser152, which increases interaction of Mash1-E47 heterodimers. We propose a novel mechanism in which the balance between Id and E protein levels regulates not only the transcriptional function but also protein stability of the neurogenic bHLH transcription factor Mash1.

BMP-2 decreases Mash1 stability by increasing Id1 expression. Publishing Authors By Initials

F ,J Reiriz,S Ambrosio,R Bartrons,JL Rosa,F Ventura,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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BMP-2 decreases Mash1 stability by increasing Id1 expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 23

Page Numbers: 3527-37

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 19

MONTH: 08

YEAR: 2004

BMP-2 decreases Mash1 stability by increasing Id1 expression. Information

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LANGUAGE: eng

NlmUniqueID: 8208664

BMP-2 decreases Mash1 stability by increasing Id1 expression. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: BMP-2 decreases Mash1 stability by increasing Id1 expression. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for BMP-2 decreases Mash1 stability by increasing Id1 expression.

AFFILIATION: Departament de Ciències Fisiològiques II, Campus de Bellvitge, Universitat de Barcelona, Feixa Llarga s/n, L'Hospitalet de Llobregat, Spain.

Country: England

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MEDLINETA: EMBO J

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