Blood purification therapy for sepsis.

Blood purification therapy for sepsis. Research Abstract Details 

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Blood purification therapy for sepsis. Abstract Text:

Hiromi Sakata,Motoki Yonekawa,Akio Kawamura,Hiromi Sakata,Motoki Yonekawa,Akio Kawamura,

Accumulating evidences of underlining pathogenesis of sepsis have contributed to the therapeutic strategy for sepsis. Not only endotoxin and cytokine, but also signal transduction through Toll-like receptors could be a strategic target for the management of sepsis. Blood purification therapy including polymyxin B-immobilized hemoperfusion cartridge and continuous hemodiafiltration has shown the beneficial effect on patients with sepsis in Japan. Although they were initially designed to remove endotoxin and cytokines respectively, they might eliminate unexpected mediators responsible for sepsis. Further elucidation of mechanism and randomized controlled studies are needed to establish the role of blood purification therapy in sepsis.

Blood purification therapy for sepsis. Publishing Authors By Initials

H Sakata,M Yonekawa,A Kawamura,H Sakata,M Yonekawa,A Kawamura,

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Blood purification therapy for sepsis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transfusion and apheresis science : official journ

VOLUME: 35

Page Numbers: 245-51

Journal Abbreviation: Transfus. Apher. Sci.

ISSN: 1473-0502

DAY: 15

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 101095653

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AFFILIATION: Department of Surgery, Sapporo Hokuyu Hospital, Research Institute for Artificial Organs, Transplantation and Gene Therapy, 6-6-5-1, Higashi Sapporo, Shiroishi-Ku, Sapporo, Hokkaido 003-0006, Japan.

Country: England

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MEDLINETA: Transfus Apher Sci

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