Blood content modulates the induction of heat shock proteins in the neurovascular network.

Blood content modulates the induction of heat shock proteins in the neurovascular network. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Blood content modulates the induction of heat shock proteins in the neurovascular network. Abstract Text:

John Kafel,Lauren Baldinger,Janet M Chabla,Brian H Hallas,Judith M Horowitz,German Torres,

Heat shock proteins are ubiquitous members of a family of molecular chaperones that protect various cell populations from injury. Up-regulation of heat shock proteins, particularly the 70 kDa species, bind selectively to denatured or partially damaged polypeptides that would otherwise perturb cell function and initiate cell death programs. In this regard, induction of heat shock proteins provides protection from cerebral ischemia in animal models of stroke. Endothelial cells, in particular, are intimately involved in the above protective event as these cells mount a stress response with induction of the 70 kDa heat shock protein. However, the coupling of heat shock proteins and the neurovascular response are not yet known. Here we show that blood content is an important factor in this stress response as rats devoid of blood content do not display a heat shock response in the microvasculature of the hippocampal formation. This lack of stress response, however, is reversed when rats are reperfused with exogenous rat or human blood content. We propose a new ischemic-sensing role for blood that serves to integrate information about protein-damaging conditions and heat shock protein levels in the neurovascular network. Further characterization of this sensing role could represent an attractive new approach to treatment of global ischemia and other microvascular pathologies.

Blood content modulates the induction of heat shock proteins in the neurovascular network. Publishing Authors By Initials

J Kafel,L Baldinger,JM Chabla,BH Hallas,JM Horowitz,G Torres,

For similar surgical procedures, operative: cardiovascular surgical procedures: reperfusion research abstracts see: surgical procedures, operative: cardiovascular surgical procedures: reperfusion research

PUBMED ID PMID:

MEDLINE DATE:

Blood content modulates the induction of heat shock proteins in the neurovascular network. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research bulletin

VOLUME: 70

Page Numbers: 304-11

Journal Abbreviation: Brain Res. Bull.

ISSN: 0361-9230

DAY: 5

MONTH: 07

YEAR: 2006

Blood content modulates the induction of heat shock proteins in the neurovascular network. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605818

Blood content modulates the induction of heat shock proteins in the neurovascular network. Keywords Mesh Terms:

KEYWORDS: Reperfusion

MESH TERMS: methods

Chemical & Substance for Abstract: Blood content modulates the induction of heat shock proteins in the neurovascular network. Information

Substance Name: HSP70 Heat-Shock Proteins

Registry Number: 0

Grant and Affiliation Information for Blood content modulates the induction of heat shock proteins in the neurovascular network.

AFFILIATION: Department of Neuroscience, New York College of Osteopathic Medicine of New York Institute of Technology, Old Westbury, NY 11568, USA.

Country: United States

AGENCY: United States NIMH

GRANT: 1R15MH64513-01A1

ACRONYM: MH

MEDLINETA: Brain Res Bull

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Blood content modulates the induction of heat shock proteins in the neurovascular network Related Publications

• A Field Study Assessing Control of Broiler Coccidiosis by Paracoxtrade mark Vaccination or by Toltrazuril (Baycox(R)) Stand-Alone Treatment.
• Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation.
• Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial.
• Blood content modulates the induction of heat shock proteins in the neurovascular network.
• Capit timed tests quantify age-related motor decline in normal subjects.
• Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme.
• Characterization of CTX-M and SHV extended-spectrum {beta}-lactamases and associated resistance genes in Escherichia coli strains of food samples in Tunisia.
• Characterization of vanA-containing Enterococcus faecium isolates carrying Tn5397-like and Tn916/Tn1545-like transposons in wild boars (Sus Scrofa).
• Computing movement geometry: a step in sensory-motor transformations.
• Discrimination of sheep susceptible and resistant to transmissible spongiform encephalopathies by an haplotype specific monoclonal antibody.
• Endothelial heat shock response in cerebral ischemia.
• Expression profile of Bag 1 in the postmortem brain.
• Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.
• Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.
• Molecular diabolos: synthesis of subphthalocyanine-based diboranes.
• Phospholipid dependence and liposome reconstitution of purified hyaluronan synthase.
• Retinal arterial and venous occlusions in patients with ADPKD.
• Strength of the Zn-N coordination bond in zinc porphyrins on the basis of experimental thermochemistry.
• Sub-soil contamination due to oil spills in zones surrounding oil pipeline-pump stations and oil pipeline right-of-ways in Southwest-Mexico.
• Successive negative contrast effect in instrumental runway behaviour: A study with Roman high- (RHA) and Roman low- (RLA) avoidance rats.
• Systematic review of randomised, double-blind clinical trials of oral agents conducted in patients with pulmonary arterial hypertension.
• The declining phase of lactation: peripheral or central, programmed or pathological?
• The effect of sperm number on fertility in blue fox vixens (Alopex lagopus ) artificially inseminated with frozen silver fox (Vulpes vulpes ) semen.
• The optimum time for single artificial insemination of blue fox vixens (Alopex lagopus ) with frozen-thawed semen from silver foxes (Vulpes vulpes ).
• Time-dependent changes in cardiac growth after kidney transplantation: the impact of pre-dialysis ventricular mass.
• Treatment failure in community-acquired pneumonia.
• [Cutaneous lesions on scars]
• [In Process Citation]
• [Occurrence of Amrineus cocofolius Flechtmann (Prostigmata: Eriophyidae) in coconut fruits (Cocos nucifera L.) in Cuba]
• [Risk adjustment measures for mortality after hip fracture]